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具有优异近红外光热活性的功能化二硫化钼纳米花用于清除抗生素耐药细菌

Functionalized MoS Nanoflowers with Excellent Near-Infrared Photothermal Activities for Scavenging of Antibiotic Resistant Bacteria.

作者信息

Liu Lulu, Wu Wanfeng, Fang Yan, Liu Haoqiang, Chen Fei, Zhang Minwei, Qin Yanan

机构信息

College of Life Science & Technology, Xinjiang University, Urumqi 830046, China.

Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, Urumqi 830046, China.

出版信息

Nanomaterials (Basel). 2021 Oct 25;11(11):2829. doi: 10.3390/nano11112829.

DOI:10.3390/nano11112829
PMID:34835597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8622428/
Abstract

Presently, antibiotic resistant bacteria (ARB) have been commonly found in environment, such as air, soil and lakes. Therefore, it is urgent and necessary to prepare antimicrobial agents with excellent anti-antibiotic resistant bacteria. In our research, poly-ethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS NFs) were synthesized via a one-step hydrothermal method. As-prepared PEG-MoS NFs displayed excellent photothermal conversion efficiency (30.6%) and photothermal stability. Under 808 nm NIR laser irradiation for 10 min, the inhibition rate of tetracycline-resistant and reached more than 95% at the concentration of 50 μg/mL. More interestingly, the photothermal effect of PEG-MoS NFs could accelerate the oxidation of glutathione, resulting in the rapid death of bacteria. A functionalized PEG-MoS NFs photothermal anti-antibiotic resistant system was constructed successfully.

摘要

目前，抗生素耐药菌（ARB）在环境中普遍存在，如空气、土壤和湖泊中。因此，制备具有优异抗抗生素耐药菌性能的抗菌剂迫在眉睫且十分必要。在我们的研究中，通过一步水热法合成了聚乙二醇功能化的二硫化钼纳米花（PEG-MoS NFs）。所制备的PEG-MoS NFs表现出优异的光热转换效率（30.6%）和光热稳定性。在808 nm近红外激光照射10分钟的情况下，在50 μg/mL的浓度下，对四环素耐药菌的抑制率达到95%以上。更有趣的是，PEG-MoS NFs的光热效应可以加速谷胱甘肽的氧化，导致细菌快速死亡。成功构建了功能化的PEG-MoS NFs光热抗抗生素耐药系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/a74886e03de3/nanomaterials-11-02829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/19f9f5e2918b/nanomaterials-11-02829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/1dbc43a7e8b7/nanomaterials-11-02829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/feba4fc3c8b0/nanomaterials-11-02829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/ff6a7fb36b4f/nanomaterials-11-02829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/b14329c03ae6/nanomaterials-11-02829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/98257f77b56c/nanomaterials-11-02829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/a74886e03de3/nanomaterials-11-02829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/19f9f5e2918b/nanomaterials-11-02829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/1dbc43a7e8b7/nanomaterials-11-02829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/feba4fc3c8b0/nanomaterials-11-02829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/ff6a7fb36b4f/nanomaterials-11-02829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/b14329c03ae6/nanomaterials-11-02829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/98257f77b56c/nanomaterials-11-02829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da02/8622428/a74886e03de3/nanomaterials-11-02829-g007.jpg

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