通过中子俘获进行放射性标记的治疗诊断用硼氮化碳纳米管（Cu-BNNTs）的潜在生产。
Potential Production of Theranostic Boron Nitride Nanotubes (Cu-BNNTs) Radiolabeled by Neutron Capture.
作者信息
Silva Wellington Marcos, Ribeiro Helio, Taha-Tijerina Jose Jaime
机构信息
Departamento de Química, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6.627, Belo Horizonte 31270-901, MG, Brazil.
Escola de Engenharia, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
出版信息
Nanomaterials (Basel). 2021 Oct 30;11(11):2907. doi: 10.3390/nano11112907.
In this work, the radioisotope Cu was obtained from copper (II) chloride dihydrate in a nuclear research reactor by neutron capture, (Cu(n,γ)Cu), and incorporated into boron nitride nanotubes (BNNTs) using a solvothermal process. The produced Cu-BNNTs were analyzed by TEM, MEV, FTIR, XDR, XPS and gamma spectrometry, with which it was possible to observe the formation ofCu nanoparticles, with sizes of up to 16 nm, distributed through nanotubes. The synthesized of Cu nanostructures showed a pure photoemission peak of 511 keV, which is characteristic of gamma radiation. This type of emission is desirable for Photon Emission Tomography (PET scan) image acquisition, as well as its use in several cancer treatments. Thus, Cu-BNNTs present an excellent alternative as theranostic nanomaterials that can be used in diagnosis and therapy by different techniques used in nuclear medicine.
在这项工作中，放射性同位素铜是通过在核研究反应堆中使二水合氯化铜（Cu(n,γ)Cu）经中子俘获获得的，并使用溶剂热法将其掺入氮化硼纳米管（BNNTs）中。通过透射电子显微镜（TEM）、微能量分析（MEV）、傅里叶变换红外光谱（FTIR）、X射线衍射（XDR）、X射线光电子能谱（XPS）和伽马能谱对所制备的铜-氮化硼纳米管进行了分析，通过这些分析能够观察到尺寸达16纳米的铜纳米颗粒的形成，这些纳米颗粒分布在纳米管中。合成的铜纳米结构显示出511千电子伏特的纯光发射峰，这是伽马辐射的特征。这种发射类型对于正电子发射断层扫描（PET扫描）图像采集以及其在多种癌症治疗中的应用是理想的。因此，铜-氮化硼纳米管作为一种可用于核医学中不同技术的诊断和治疗的治疗诊断纳米材料，是一种极佳的选择。
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