Nutritional Biology, Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands.
Department of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Nutrients. 2021 Nov 1;13(11):3923. doi: 10.3390/nu13113923.
Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient deficiencies in pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) patients.
Eighty-one blood samples from a prospective observational cohort study were analyzed for concentrations of micronutrients and inflammation-related factors. The samples consisted of newly diagnosed (treatment-naive) PAH and CTEPH patients and patients treated for 1.5 years according to ERS/ESC guidelines.
In the newly diagnosed group, 42% of PAH patients and 21% of CTEPH patients were iron deficient compared to 29% of PAH patients and 20% of CTEPH patients in the treatment group. Vitamin D deficiency occurred in 42% of the newly diagnosed PAH patients, 71% of the newly diagnosed CTEPH patients, 68% of the treated PAH patients, and 70% of the treated CTEPH patients. Iron levels correlated with the 6 min walking distance (6MWD).
Iron and vitamin D deficiencies are highly prevalent in PAH and CTEPH patients, underlining the need for monitoring their status. Studies evaluating the effects of supplementation strategies for iron and vitamin D are necessary.
肺动脉高压（PH）是一种罕见的进行性和致命性疾病，影响肺动脉和心脏功能。该疾病可能会影响患者的营养状况，从而损害其身体机能。本研究旨在确定肺动脉高压（PAH）和慢性血栓栓塞性肺动脉高压（CTEPH）患者中微量营养素缺乏的患病率。
对一项前瞻性观察队列研究的 81 份血样进行了分析，以检测微量营养素和炎症相关因素的浓度。这些样本包括新诊断（未经治疗）的 PAH 和 CTEPH 患者，以及根据 ERS/ESC 指南治疗 1.5 年的患者。
在新诊断组中，42%的 PAH 患者和 21%的 CTEPH 患者存在铁缺乏，而治疗组中 PAH 患者和 CTEPH 患者分别为 29%和 20%。新诊断的 PAH 患者中维生素 D 缺乏的发生率为 42%，新诊断的 CTEPH 患者为 71%，治疗的 PAH 患者为 68%，治疗的 CTEPH 患者为 70%。铁水平与 6 分钟步行距离（6MWD）相关。
铁和维生素 D 缺乏在 PAH 和 CTEPH 患者中非常普遍，这突出表明需要监测其状态。评估铁和维生素 D 补充策略效果的研究是必要的。
