Pache-Wannaz Laure, Voicu Cristiana, Boillat Laurence, Sekarski Nicole
Pediatric Cardiology, Women-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Pediatric Intensive Care Unit, Women-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Front Pediatr. 2025 Jan 31;13:1478889. doi: 10.3389/fped.2025.1478889. eCollection 2025.
We describe the rare case of a previously healthy seven year-old boy, with an acute clinical onset of severe pulmonary hypertension. He recovered rapidly after vitamin supplementation. Patient history showed a highly selective food intake in the context of autistic features. Thiamine deficiency seemed to be the predominant causing factor aggravated by moderate iron deficiency and supposed vitamin C deficiency. Dietary impact on pulmonary pressures is still poorly understood, but it seems that micronutrient deficiency could be a rare cause of pulmonary hypertension. Relatively frequent in developing countries and mostly in infants, thiamine deficiency should not be forgotten as a potential etiology in the differential diagnosis when patient dietary history is particular.
我们描述了一名此前健康的7岁男孩的罕见病例，他急性起病，出现严重肺动脉高压。补充维生素后他迅速康复。患者病史显示在患有自闭症特征的情况下存在高度选择性的食物摄入。硫胺素缺乏似乎是主要病因，中度缺铁和推测的维生素C缺乏使其加重。饮食对肺动脉压力的影响仍知之甚少，但微量营养素缺乏似乎可能是肺动脉高压的一个罕见病因。硫胺素缺乏在发展中国家相对常见，且大多发生在婴儿中，当患者饮食史特殊时，在鉴别诊断中不应忘记将其作为一种潜在病因。
