College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Shennongjia Science & Technology Innovation Center, Huazhong Agricultural University, Wuhan 430070, China.
Nutrients. 2021 Nov 5;13(11):3953. doi: 10.3390/nu13113953.
Plant polyphenols are the main category of natural active substances, and are distributed widely in vegetables, fruits, and plant-based processed foods. Polyphenols have a beneficial performance in preventing diseases and maintaining body health. However, its action mechanism has not been well understood. Foodomics is a novel method to sequence and widely used in nutrition, combining genomics, proteomics, transcriptomics, microbiome, and metabolomics. Based on multi-omics technologies, foodomics provides abundant data to study functional activities of polyphenols. In this paper, physiological functions of various polyphenols based on foodomics and microbiome was discussed, especially the anti-inflammatory and anti-tumor activities and gut microbe regulation. In conclusion, omics (including microbiomics) is a useful approach to explore the bioactive activities of polyphenols in the nutrition and health of human and animals.
植物多酚是天然活性物质的主要类别，广泛分布于蔬菜、水果和植物性加工食品中。多酚在预防疾病和维护身体健康方面具有有益的作用。然而，其作用机制尚未得到很好的理解。食品组学是一种新的测序方法，广泛应用于营养领域，结合了基因组学、蛋白质组学、转录组学、微生物组学和代谢组学。基于多组学技术，食品组学提供了丰富的数据来研究多酚的功能活性。本文讨论了基于食品组学和微生物组学的各种多酚的生理功能，特别是抗炎和抗肿瘤活性以及肠道微生物调节。总之，组学（包括微生物组学）是探索多酚在人类和动物营养与健康中的生物活性的有用方法。
