Department of Clinical Sciences Malmö, Lund University, 20502 Malmö, Sweden.
Nutrients. 2021 Nov 5;13(11):3954. doi: 10.3390/nu13113954.
Hereditary mechanisms are partially responsible for individual differences in sensitivity to and the preference for sweet taste. The primary aim of this study was to examine the associations between 10 genetic variants and the intake of total sugar, added sugar, and sugars with sweet taste (i.e., monosaccharides and sucrose) in a middle-aged Swedish population. Two single nucleotide polymorphisms (SNPs) within the gene, seven top hits from a genome-wide association study (GWAS) on total sugar intake, and one SNP within the fat mass and obesity associated () gene (the only SNP reaching GWAS significance in a previous study), were explored in relation to various forms of sugar intake in 22,794 individuals from the Malmö Diet and Cancer Study, a population-based cohort for which data were collected between 1991-1996. Significant associations ( = 6.82 × 10 - 1.53 × 10) were observed between three SNPs (rs838145, rs838133, and rs8103840) in close relation to the gene with high Linkage Disequilibrium, and all the studied sugar intakes. For the rs11642841 within the gene, associations were found exclusively among participants with a body mass index ≥ 25 ( < 5 × 10). None of the remaining SNPs studied were associated with sugar intake in our cohort. A further GWAS should be conducted to identify novel genetic variants associated with the intake of sugar.
遗传机制在一定程度上导致了个体对甜味的敏感度和偏好存在差异。本研究的主要目的是检验 10 个基因变异与总糖、添加糖和具有甜味的糖（即单糖和蔗糖）摄入量之间的关联，研究对象为瑞典一个中年人群的中，纳入了 22794 名来自马尔默饮食与癌症研究（Malmö Diet and Cancer Study）的个体。该研究是一个基于人群的队列研究，数据收集于 1991-1996 年。在这些个体中，我们研究了 基因内的 2 个单核苷酸多态性（SNP）、全基因组关联研究（GWAS）中与总糖摄入量相关的 7 个高分 hits，以及 基因内的 1 个 SNP（这是之前的研究中唯一达到 GWAS 显著性的 SNP）与各种形式的糖摄入量之间的关系。在与 基因密切相关且高度连锁不平衡的 3 个 SNP（rs838145、rs838133 和 rs8103840）中，观察到与高 Linkage Disequilibrium 相关的三个 SNPs（rs838145、rs838133 和 rs8103840）与所有研究中的糖摄入量均存在显著关联（ = 6.82 × 10 - 1.53 × 10）。在 基因内的 rs11642841 中，仅在 BMI ≥ 25 的参与者中发现了关联（ < 5 × 10）。在我们的队列中，没有发现其余研究的 SNP 与糖摄入量相关。应该进行进一步的 GWAS 以鉴定与糖摄入相关的新的遗传变异。
