Maragheh University of Medical Sciences, Maragheh, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr Metab Cardiovasc Dis. 2019 May;29(5):474-480. doi: 10.1016/j.numecd.2019.01.005. Epub 2019 Feb 1.
The results of studies on the effect of trans-fatty acids (TFAs) and added sugars on obesity are not consistent. This study aimed to investigate whether the association of changes in general and central obesity with added sugar and TFA intakes is modified by common fat mass and obesity-associated gene (FTO) polymorphisms, in isolation or in a combined-form genetic risk score (GRS).
Subjects of this cohort study were selected from among adult participants of the Tehran Lipid and Glucose Study (n = 4292, 43.2% male). Dietary data were collected using a valid and reliable food frequency questionnaire. The genotypes of selected polymorphisms (rs1421085, rs1121980, and rs8050136) were determined. Genetic risk score (GRS) was calculated using the dominant weighted method. The mean age of participants was 42.6 ± 14 and 40.4 ± 13 years in men and women, respectively. FTO rs8050136 polymorphisms and TFAs have a significant interaction in changing body mass index (BMI) (P interaction = 0.01). There were no changes in waist circumference (WC) and BMI among FTO risk allele carriers, across quartiles of added sugar intake. GRS and TFA intakes significantly interacted in altering the BMI and WC; thus, a higher intake of TFAs was associated with higher changes of BMI and WC in subjects with high GRS (P trend<0.05) compared to individuals with low GRS.
Our findings suggest that TFA intake can increase the genetic susceptibility of FTO SNPs to BMI or WC change.
反式脂肪酸（TFAs）和添加糖对肥胖影响的研究结果并不一致。本研究旨在探讨一般和中心性肥胖变化与添加糖和 TFA 摄入量之间的关联是否因常见的脂肪质量和肥胖相关基因（FTO）多态性而改变，无论是单独存在还是作为联合形式的遗传风险评分（GRS）。
本队列研究的受试者选自德黑兰血脂和血糖研究（Tehran Lipid and Glucose Study，TLGS）的成年参与者（n=4292，43.2%为男性）。使用有效的和可靠的食物频率问卷收集膳食数据。选择的多态性（rs1421085、rs1121980 和 rs8050136）的基因型通过聚合酶链式反应确定。使用显性加权法计算遗传风险评分（GRS）。参与者的平均年龄为 42.6±14 岁，男性和女性分别为 40.4±13 岁。FTO rs8050136 多态性和 TFA 在改变体重指数（BMI）方面存在显著的相互作用（P 交互=0.01）。在添加糖摄入量的四分位数中，FTO 风险等位基因携带者的腰围（WC）和 BMI 没有变化。GRS 和 TFA 摄入量在改变 BMI 和 WC 方面存在显著的相互作用；因此，在 GRS 较高的人群中，TFA 的摄入量较高与 BMI 和 WC 的变化较高相关（P 趋势<0.05），而在 GRS 较低的人群中则没有相关性。
我们的研究结果表明，TFA 的摄入可能会增加 FTO SNP 对 BMI 或 WC 变化的遗传易感性。
