Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.
Department of General Internal Medicine, Hiroshima University Hospital, Kasumi 1-2-3, Minami-Ku, Hiroshima 734-8551, Japan.
Nutrients. 2021 Nov 11;13(11):4022. doi: 10.3390/nu13114022.
We have recently demonstrated that the exopolysaccharides (EPSs) produced by a plant-derived lactic acid bacterium, IJH-SONE68, prevent and ameliorate allergic reaction on contact in dermatitis model mice. In the present study, we conducted a clinical trial using a capsule containing spray-dried powder from pineapple juice broth fermented with the LAB strain as an experimental diet. The clinical trial was conducted as a double-blind and placebo-controlled randomized comparative study from May 2019 to July 2021. Males and females between the ages of 21 and 70 who experience chronic allergies participated in the study. Sixty subjects were instructed to orally take a capsule containing the IJH-SONE68 powder or placebo, every day for 12 weeks. After the clinical trial was over, the scores based on subjects' self-assessment of allergic status were significantly improved in the intervention group, as compared with the placebo group. Some serum biochemicals associated with inflammation response were also significantly improved by intake of the experimental diet. In conclusion, the IJH-SONE68-derived EPS improves chronic allergy status in humans and is expected to decrease their inconvenience.
我们最近证实，植物乳杆菌 IJHSONE68 产生的胞外多糖（EPS）可预防和改善接触性皮炎模型小鼠的过敏反应。在本研究中，我们使用含有菠萝汁发酵液喷雾干燥粉末的胶囊作为实验饮食进行了临床试验。该临床试验是一项双盲、安慰剂对照的随机对照研究，于 2019 年 5 月至 2021 年 7 月进行。年龄在 21 至 70 岁之间患有慢性过敏症的男性和女性参加了该研究。60 名受试者被指示每天口服含有 IJHSONE68 粉末的胶囊或安慰剂，持续 12 周。临床试验结束后，与安慰剂组相比，干预组基于受试者对过敏状况自我评估的评分显著改善。摄入实验饮食还显著改善了一些与炎症反应相关的血清生化指标。总之，IJH-SONE68 衍生的 EPS 改善了人类的慢性过敏状况，有望减轻他们的不便。
