Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Pak J Pharm Sci. 2021 Sep;34(5(Supplementary)):1879-1884.
The present study was designed to evaluate the antipyretic and antinociceptive activities of R. communis leaves and W. somnifera roots hydroalcoholic extracts in Wistar rats. To assess the antipyretic activity, Brewer's yeast suspension was used to induce hyperthermia. Antinociceptive activity was observed using acetic acid-induced abdominal writhing, formalin-induced paw licking reflex and heat-induced pain models. R. communis and W. somnifera extracts were used at 150, 250 and 500mg/kg. Results showed that administration of both plants significantly (p<0.001) lowered rectal temperature (°C) in a dose-dependent manner from 1h to 4h of study. R. communis and W. somnifera extracts showed a dose-dependent reduction in abdominal writhing induced by acetic acid and decreased the paw licking reflex in formalin-induced nociceptive response. In the heat test, R. communis and W. somnifera extracts exhibited significant (p<0.001) analgesic effects evidenced as an increase in latency time. However, R. communis exhibited prominent antipyretic and antinociceptive activities at 250 and 500mg/kg as compared to W. somnifera. Conclusively, R. communis and W. somnifera could be a potential source of antipyretic and analgesic agents which require further studies.
本研究旨在评估 R. communis 叶和 W. somnifera 根水醇提取物在 Wistar 大鼠中的解热和镇痛活性。为了评估解热活性，使用啤酒酵母悬浮液诱导发热。通过醋酸诱导的腹部扭曲、福尔马林诱导的舔足反射和热诱导疼痛模型观察镇痛活性。使用 R. communis 和 W. somnifera 提取物的剂量为 150、250 和 500mg/kg。结果表明，两种植物的给药均能显著（p<0.001）降低直肠温度（°C），呈剂量依赖性，从研究的 1 小时到 4 小时。R. communis 和 W. somnifera 提取物对醋酸诱导的腹部扭曲呈剂量依赖性减少，并降低福尔马林诱导的疼痛反应中的舔足反射。在热试验中，R. communis 和 W. somnifera 提取物表现出显著的（p<0.001）镇痛作用，表现为潜伏期延长。然而，与 W. somnifera 相比，R. communis 在 250 和 500mg/kg 时表现出突出的解热和镇痛活性。总之，R. communis 和 W. somnifera 可能是解热和镇痛剂的潜在来源，需要进一步研究。
