蓖麻叶的抗伤害感受活性。
Antinociceptive activity of Ricinus communis L. leaves.
作者信息
Taur Dnyaneshwar J, Waghmare Maruti G, Bandal Rajendra S, Patil Ravindra Y
机构信息
Department of Pharmacognosy, SVPM's College of Pharmacy, Malegaon (bk), Baramati, Maharashtra, India.
出版信息
Asian Pac J Trop Biomed. 2011 Apr;1(2):139-41. doi: 10.1016/S2221-1691(11)60012-9.
Abstract
OBJECTIVE
To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL).
METHODS
Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw.
RESULTS
The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in mice. Preliminary phytochemical analysis suggested the presence of saponin, steroids and alkaloids.
CONCLUSIONS
It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin, steroids and alkaloids in it.
摘要
目的
评估蓖麻叶甲醇提取物（MRCL）的抗伤害感受活性。
方法
采用醋酸诱导扭体试验、福尔马林诱导舔足试验和小鼠尾部浸浴法，以100、125和150mg/kg体重的剂量评估其抗伤害感受活性。
结果
结果表明，MRCL对小鼠三种经典疼痛模型表现出显著的抗伤害感受活性。初步植物化学分析表明存在皂苷、甾体和生物碱。
结论
可以得出结论，MRCL具有抗伤害感受潜力，这可能归因于其中的皂苷、甾体和生物碱。
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