Electrochemistry Coupling Localized Surface Plasmon Resonance for Biochemical Detection.

Localized surface plasmon resonance (LSPR) associated with metal nanostructures has developed into highly useful sensor techniques. LSPR spectroscopy often shows absorption peaks which could be used for biomedical detection. Here we report nanoplasmonic sensors using LSPR on nanostructures such as nanoparticles, nanocups, and nanocones to recognize biomolecular. These sensors can be modified for quantitative detection of explosives and evaluation of enzymatic activity. Electrochemical LSPR sensors can also be designed by coupling electrochemistry and LSPR spectroscopy measurements for biochemical detection. Multiple sensing information can be obtained and electrochemical LSPR property can be investigated for biosensors. In some applications, the electrochemical LSPR biosensor can be used to quantify heavy metal ions, neurotransmitters, and sialic acid. The biosensors exhibit better performance than those of conventional optical LSPR measurements. With multitransducers, the nanoplasmonic biosensor can provide a promising approach for biochemical detection in environmental monitoring, healthcare diagnostics, and food quality control.