甘草多糖可改善和延长鸡对新城疫疫苗的应答反应。

Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine.

机构信息

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, PR China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, PR China.

Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing 102206, PR China.

出版信息

Poult Sci. 2022 Jan;101(1):101549. doi: 10.1016/j.psj.2021.101549. Epub 2021 Oct 16.

Licorice is a medicinal and food plant widely used to treat diseases and produce food additives, because of its unique chemical constituents like polysaccharides, flavones, and saponins. Glycyrrhiza Polysaccharides (GPS-1) are water-soluble neutral polysaccharides extracted from licorice. Currently, GPS-1 is administrated to chickens by gavage every d for 14 d to observe the impact of GPS-1 on the Newcastle disease vaccine. To determine the immunity of these chickens to NDV, blood serum levels of hemagglutinin-inhibition (HI) antibody, and immunoglobulins IgA and IgG were measured. Meanwhile, the expression levels of cytokines IL-2, IL-4, IL-17, and IFN-γ were measured to evaluate the degree of immune booster activity. The chickens' spleen and peripheral blood lymphocytes displayed a significant increase in the proportion of CD4+ and CD8+ T cells after booster treatments with GPS-1. The results indicated that GPS-1 had a significant, dose-dependent, immune-boosting effect which could enhance NDV vaccine immunity in chickens.

甘草是一种药用和食用植物，广泛用于治疗疾病和生产食品添加剂，因为它具有独特的化学成分，如多糖、黄酮和皂苷。甘草多糖（GPS-1）是从甘草中提取的水溶性中性多糖。目前，通过灌胃的方式给鸡 GPS-1，每天一次，连续 14 天，以观察 GPS-1 对新城疫疫苗的影响。为了确定这些鸡对 NDV 的免疫力，测量了血清血凝抑制（HI）抗体和免疫球蛋白 IgA 和 IgG 的水平。同时，还测量了细胞因子 IL-2、IL-4、IL-17 和 IFN-γ 的表达水平，以评估免疫增强剂的活性程度。GPS-1 增强后，鸡的脾脏和外周血淋巴细胞中 CD4+和 CD8+T 细胞的比例显著增加。结果表明，GPS-1 具有显著的、剂量依赖性的免疫增强作用，可以增强鸡对 NDV 疫苗的免疫力。