Vessby B, Lithell H, Boberg J, Hellsing K
Clin Pharmacol Ther. 1978 Jun;23(6):651-7. doi: 10.1002/cpt1978236651.
The capacity of para-aminosalicylic acid (PAS) to lower initially high serum lipoprotein lipid concentrations was tested in a double-blind crossover study. Thirty patients who were on a lipid-lowering diet were treated with PAS (6 gm daily) for 4 wk. There was an average reduction of the serum triglyceride concentration of 28% (p less than 0.001) and of 12% of the serum cholesterol concentration (p less than 0.001) corresponding to a reduction of very low density lipoprotein (VLDL) triglycerides of 40% (p less than 0.001) and low density lipoprotein (LDL) cholesterol of 6% (p less than 0.05). In hypercholesterolemic patients, the LDL cholesterol reduction was 14% (p less than 0.001). In patients with hypertriglyceridemia type IV, the mean reduction of the VLDL triglyceride concentration was 47% (p less than 0.01), corresponding to a serum triglyceride reduction by 37% (p less than 0.01). In spite of the decrease of VLDL concentration, there was an unexpected reduction of the lipoprotein lipase activity in adipose tissue of 16% (p less than 0.02). The glucose tolerance and the serum insulin concentrations at fasting and after glucose injection were not changed.
在一项双盲交叉研究中，对对氨基水杨酸（PAS）降低初始较高血清脂蛋白脂质浓度的能力进行了测试。30名接受降脂饮食的患者接受PAS（每日6克）治疗4周。血清甘油三酯浓度平均降低28%（p<0.001），血清胆固醇浓度降低12%（p<0.001），相应地极低密度脂蛋白（VLDL）甘油三酯降低40%（p<0.001），低密度脂蛋白（LDL）胆固醇降低6%（p<0.05）。在高胆固醇血症患者中，LDL胆固醇降低14%（p<0.001）。在IV型高甘油三酯血症患者中，VLDL甘油三酯浓度平均降低47%（p<0.01），相应地血清甘油三酯降低37%（p<0.01）。尽管VLDL浓度降低，但脂肪组织中的脂蛋白脂肪酶活性意外降低了16%（p<0.02）。空腹及注射葡萄糖后的葡萄糖耐量和血清胰岛素浓度未发生变化。
