Goldberg A P, Chen M, Brunzell J D, Bierman E L, Porte D
Metabolism. 1978 Nov;27(11):1648-60. doi: 10.1016/0026-0495(78)90287-1.
The effect of para-aminosalicylic acid-C (PAS-C, 8 g/day) on lipid metabolism was studied on a metabolic ward in nine subjects with primary endogenous hypertriglyceridemia. During 2 wk on a basal isocaloric liquid formula diet (40% fat, 45% carbohydrate), PAS-C reduced plasma triglyceride (-41.9 +/- 18.9%, p less than .01, -x +/- SD), cholesterol (-22.8 +/- 12.9%, p less than .005), and a very low density lipoprotein triglyceride (p less than .001) and cholesterol (p less than .01) levels without changing the cholesterol content of low density or high density lipoproteins. Similar effects occurred on a fat-free, 85% carbohydrate diet. Decreases in very low density lipoproteins correlated with changes in both total triglyceride (r = .99, p less than .01) and cholesterol (r = .70, p less than .05). Treatment with PAS-C reduced the plasma triglyceride removal rate related to lipoprotein lipase (-14.6 +/- 14.1%, p less than .02), but did not alter plasma postheparin lipolytic activity or the apparent Km for substrate-enzyme interaction. Kinetic data obtained during the prolonged heparin infusion fit the linearized Michaelis-Menten model for subjects with endogenous hypertriglyceridemia. The reduction in the plasma triglyceride concentration during PAS-C treatment was a function of the decrease in triglyceride removal rate (r = .74, p less than .025) without alternation in the maximal removal capacity related to lipoprotein lipase. This suggests that under the steady state conditions of these studies, the decrease in plasma triglyceride concentration was due to a reduction in endogenous triglyceride production. Free fatty acid metabolism, glucose homeostasis, fat absorption, and thyroid function did not change. These results suggest that PAS-C lowers plasma triglyceride and cholesterol levels in hypertriglyceridemic subjects reducing endogenous very low density lipoprotein production and/or secretion into the circulation.
在代谢病房对9名原发性内源性高甘油三酯血症患者研究了对氨基水杨酸C（PAS-C，8克/天）对脂质代谢的影响。在基础等热量液体配方饮食（40%脂肪，45%碳水化合物）的2周期间，PAS-C降低了血浆甘油三酯（-41.9±18.9%，p<0.01，均值±标准差）、胆固醇（-22.8±12.9%，p<0.005）以及极低密度脂蛋白甘油三酯（p<0.001）和胆固醇（p<0.01）水平，而未改变低密度或高密度脂蛋白的胆固醇含量。在无脂肪、85%碳水化合物饮食时也出现了类似效果。极低密度脂蛋白的降低与总甘油三酯（r = 0.99，p<0.01）和胆固醇（r = 0.70，p<0.05）的变化相关。PAS-C治疗降低了与脂蛋白脂肪酶相关的血浆甘油三酯清除率（-14.6±14.1%，p<0.02），但未改变血浆肝素后脂解活性或底物-酶相互作用的表观米氏常数。在延长肝素输注期间获得的动力学数据符合内源性高甘油三酯血症患者的线性化米氏模型。PAS-C治疗期间血浆甘油三酯浓度的降低是甘油三酯清除率降低的函数（r = 0.74，p<0.025），而与脂蛋白脂肪酶相关的最大清除能力未改变。这表明在这些研究的稳态条件下，血浆甘油三酯浓度的降低是由于内源性甘油三酯生成减少。游离脂肪酸代谢、葡萄糖稳态、脂肪吸收和甲状腺功能未改变。这些结果表明，PAS-C降低了高甘油三酯血症患者的血浆甘油三酯和胆固醇水平，减少了内源性极低密度脂蛋白的生成和/或分泌入循环。
