Department of Gastroenterology, Clinical Medical College, Yangzhou University, No 98, Nantong West Rd, Yangzhou, Jiangsu Province, 225000, China.
School of Nursing, Yangzhou University, Yangzhou, China.
Lipids Health Dis. 2021 Nov 27;20(1):171. doi: 10.1186/s12944-021-01597-4.
The effect of comorbid hypertriglyceridemia (HTG) and abdominal obesity (AO) on acute pancreatitis (AP) remains unclear. The aim of this study was to explore the effect of comorbid HTG and AO and discuss which is the dominant disorder.
In this study, 1219 AP patients who presented with HTG or AO were stratified into four groups: non-HTG + non-AO, HTG + non-AO, non-HTG + AO, and HTG + AO.
The 328 patients with comorbid HTG + AO were much younger (42.29 ± 11.77), mainly male (79.57%), and had higher TG levels, larger waist circumferences, and more past medical histories than the patients in the other three non-comorbid groups (P < 0.001). The comorbidity group developed more incidences of persistent organ failure and local complications (P < 0.05). Multivariate logistic regression analysis showed that AO (OR = 3.205, 95% CI = 1.570-6.544), mild HTG (OR = 2.746, 95% CI = 1.125-6.701), and moderate to very severe HTG (OR = 3.649, 95% CI = 1.403-9.493) were independent risk factors for persistent respiratory failure (P < 0.05). Age > 60 years (OR = 1.326, 95% CI = 1.047-1.679), AO (OR = 1.701, 95% CI = 1.308-2.212), diabetes mellitus (OR = 1.551, 95% CI = 1.063-2.261), mild HTG (OR = 1.549, 95% CI = 1.137-2.112), and moderate to very severe HTG (OR = 2.810, 95% CI = 1.926-4.100) were independent risk factors associated with local complications (P < 0.05). Moreover, HTG seemed to be more dangerous than AO. The higher the serum TG level was, the greater the likelihood of persistent respiratory failure and local complications.
Comorbid HTG and AO will aggravate the severity and increase the incidence of local complications of AP. HTG may play a dominant role of risk in the condition of comorbidity.
ChiCTR2100049566 . Registered on 3 August, 2021. Retrospectively registered, https://www.chictr.org.cn/edit.aspx?pid=127374&htm=4 .
合并高甘油三酯血症（HTG）和腹型肥胖（AO）对急性胰腺炎（AP）的影响仍不清楚。本研究旨在探讨合并 HTG 和 AO 的影响，并讨论哪种疾病是主要的致病因素。
在这项研究中，将 1219 例出现 HTG 或 AO 的 AP 患者分为四组：非 HTG+非 AO、HTG+非 AO、非 HTG+AO 和 HTG+AO。
328 例合并 HTG+AO 的患者年龄明显更小（42.29±11.77），主要为男性（79.57%），且甘油三酯水平更高，腰围更大，既往病史更多，与其他三组非合并组相比差异有统计学意义（P<0.001）。合并组的持续性器官衰竭和局部并发症的发生率更高（P<0.05）。多变量 logistic 回归分析显示，AO（OR=3.205，95%CI=1.570-6.544）、轻度 HTG（OR=2.746，95%CI=1.125-6.701）和中重度 HTG（OR=3.649，95%CI=1.403-9.493）是持续性呼吸衰竭的独立危险因素（P<0.05）。年龄>60 岁（OR=1.326，95%CI=1.047-1.679）、AO（OR=1.701，95%CI=1.308-2.212）、糖尿病（OR=1.551，95%CI=1.063-2.261）、轻度 HTG（OR=1.549，95%CI=1.137-2.112）和中重度 HTG（OR=2.810，95%CI=1.926-4.100）是局部并发症的独立危险因素（P<0.05）。此外，HTG 似乎比 AO 更危险。血清甘油三酯水平越高，持续性呼吸衰竭和局部并发症的可能性就越大。
合并 HTG 和 AO 会加重 AP 的严重程度，并增加局部并发症的发生率。HTG 在合并症的情况下可能发挥主要的致病作用。
ChiCTR2100049566。注册于 2021 年 8 月 3 日。前瞻性注册，https://www.chictr.org.cn/edit.aspx?pid=127374&htm=4。
