Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 386 Hanjiang Media Road, Yangzhou, 225000, Jiangsu, China.
Laboratory of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 386 Hanjiang Media Road, Yangzhou, 225000, Jiangsu, China.
Lipids Health Dis. 2019 Apr 9;18(1):93. doi: 10.1186/s12944-019-1019-2.
The aim of this study was to evaluate the effect of a simple visceral obesity phenotype, known as the hypertriglyceridemic waist phenotype and its quantitative indicator waist circumference index on the severity of acute pancreatitis.
Diagnosis and severity analysis of acute pancreatitis were determined according to the Atlanta classification guidelines, revised in 2012. We considered the hypertriglyceridemic waist phenotype as characterized by increased waist circumference and elevated triglyceride concentrations. We investigated the association between the acute pancreatitis severity and hypertriglyceridemic waist phenotype, including waist circumference index.
The hypertriglyceridemic waist phenotype was significantly associated with systemic inflammatory response syndrome, organ failure, and severe acute pancreatitis. The median waist circumference index and demonstration of hypertriglyceridemic waist phenotype were positively correlated with acute pancreatitis severity. In addition, multivariate logistic analysis showed that patients with the hypertriglyceridemic waist phenotype had 1.664 times the risk of organ failure and 1.891 times the risk of systemic inflammatory response syndrome, compared with the other groups.
Upon admission, the hypertriglyceridemic waist phenotype was strongly associated with acute pancreatitis in patients. This phenotype, including waist circumference index, might be a simple method for evaluating individuals at high risk of severe acute pancreatitis.
本研究旨在评估一种简单的内脏肥胖表型（即高甘油三酯性腰围表型及其定量指标腰围指数）对急性胰腺炎严重程度的影响。
根据 2012 年修订的亚特兰大分类指南确定急性胰腺炎的诊断和严重程度分析。我们将高甘油三酯性腰围表型定义为腰围增加和甘油三酯浓度升高。我们研究了急性胰腺炎严重程度与高甘油三酯性腰围表型（包括腰围指数）之间的关系。
高甘油三酯性腰围表型与全身炎症反应综合征、器官衰竭和重症急性胰腺炎显著相关。中位数腰围指数和高甘油三酯性腰围表型的表现与急性胰腺炎严重程度呈正相关。此外，多变量逻辑分析显示，与其他组相比，高甘油三酯性腰围表型患者发生器官衰竭的风险增加 1.664 倍，发生全身炎症反应综合征的风险增加 1.891 倍。
入院时，高甘油三酯性腰围表型与患者的急性胰腺炎密切相关。这种表型，包括腰围指数，可能是评估重症急性胰腺炎高危个体的一种简单方法。
