Remenapp A, Coyle K, Orange T, Lynch T, Hooper D, Hooper S, Conway K, Hausenblas H A
Center for Health and Human Performance, Jacksonville University, USA.
Center for Health and Human Performance, Jacksonville University, USA.
J Ayurveda Integr Med. 2022 Apr-Jun;13(2):100510. doi: 10.1016/j.jaim.2021.08.003. Epub 2021 Nov 25.
The present study examined the effects of a proprietary Ashwagandha (Withania somnifera) root and leaf extract (NooGandha® Specnova LLC, USA) supplement for improving cognitive abilities, cortisol levels, and self-reported mood, stress, food cravings, and anxiety with adults who have perceived stress. Healthy adults (n = 43 women and n = 17 men; mean age = 34.41 years) who reported experiencing perceived stress were randomized to the following groups: Ashwagandha (400 mg/d), Ashwagandha (225 mg/d), and placebo for 30 days. The following outcomes were assessed at Day 0, Day 15, and Day 30: saliva cortisol levels, cognitive performance (i.e., CNS vital signs), and the self-reported measures of Trait Anxiety Inventory, Depression Anxiety Stress Scale, Perceived Stress Scale, and Food Cravings Questionnaire-15. For the self-report assessments, significant main effects for time were evidenced for anxiety, depression, perceived stress, and food cravings, p's < 0.01. The main effect for group and the interactions were non-significant. For the CNS vital signs, significant differences were observed in cognitive flexibility, visual memory, reaction time, psychomotor speed, and executive functioning, p's < 0.05, with the Ashwagandha groups often out-performing the placebo group. Both Ashwagandha groups had reductions in cortisol levels over time, with significant reductions evidenced for the Ashwagandha 225 mg/d group from Day 0 to Day 15 to Day 30. The placebo group had a non-significant increase in cortisol levels from Day 0 to Day 15-30. No adverse events were reported. In conclusion, Ashwagandha supplementation may improve the physiological, cognitive, and psychological effects of stress.
本研究考察了一种专利印度人参（南非醉茄）根和叶提取物（NooGandha® Specnova LLC，美国）补充剂对改善认知能力、皮质醇水平以及自我报告的情绪、压力、食物渴望和焦虑的效果，研究对象为有感知压力的成年人。报告有感知压力的健康成年人（43名女性和17名男性；平均年龄 = 34.41岁）被随机分为以下几组：印度人参组（400毫克/天）、印度人参组（225毫克/天）和安慰剂组，为期30天。在第0天、第15天和第30天评估以下指标：唾液皮质醇水平、认知表现（即中枢神经系统生命体征）以及特质焦虑量表、抑郁焦虑压力量表、感知压力量表和食物渴望问卷 - 15的自我报告测量值。对于自我报告评估，焦虑、抑郁、感知压力和食物渴望在时间上有显著的主效应，p值<0.01。组间主效应和交互作用不显著。对于中枢神经系统生命体征，在认知灵活性、视觉记忆、反应时间、心理运动速度和执行功能方面观察到显著差异，p值<0.05，印度人参组通常表现优于安慰剂组。两个印度人参组的皮质醇水平随时间都有所降低，从第0天到第15天再到第30天，225毫克/天印度人参组有显著降低。安慰剂组从第0天到第15 - 30天皮质醇水平有不显著的升高。未报告不良事件。总之，补充印度人参可能改善压力的生理、认知和心理影响。
