Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Trivandrum 695 019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Trivandrum 695 019, Kerala, India.
Bioresour Technol. 2022 Feb;346:126410. doi: 10.1016/j.biortech.2021.126410. Epub 2021 Nov 24.
Diols are important platform chemicals with extensive industrial applications in biopolymer synthesis, cosmetics, and fuels. The increased dependence on non-renewable sources to meet the energy requirement of the population raised issues regarding fossil fuel depletion and environmental impacts. The utilization of biological methods for the synthesis of diols by utilizing renewable resources such as glycerol and agro-residual wastes gained attention worldwide because of its advantages. Among these, biotransformation of 1,3-propanediol (1,3-PDO) and 2,3-butanediol (2,3-BDO) were extensively studied and at present, these diols are produced commercially in large scale with high yield. Many important isomers of C2-C4 diols lack natural synthetic pathways and development of chassis strains for the synthesis can be accomplished by adopting synthetic biology approaches. This current review depicts an overall idea about the pathways involved in C2-C4 diol production, metabolic intervention strategies and technologies in recent years.
二醇是一类重要的平台化学品，在生物聚合物合成、化妆品和燃料等领域具有广泛的工业应用。人们对不可再生资源的依赖程度不断增加，以满足人口的能源需求，这引发了人们对化石燃料枯竭和环境影响的关注。利用生物方法，利用可再生资源如甘油和农业残余废物合成二醇，因其具有优势而受到全球关注。在这些方法中，1,3-丙二醇（1,3-PDO）和 2,3-丁二醇（2,3-BDO）的生物转化得到了广泛的研究，目前，这些二醇已经可以大规模、高产量地商业化生产。C2-C4 二醇的许多重要异构体缺乏天然的合成途径，通过采用合成生物学方法可以开发用于合成的底盘菌株。本综述描述了 C2-C4 二醇生产途径、近年来代谢干预策略和技术的总体思路。
