Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestr. 15, D-21071 Hamburg, Germany.
Curr Opin Biotechnol. 2011 Dec;22(6):749-57. doi: 10.1016/j.copbio.2011.05.005. Epub 2011 Jun 7.
Diols are chemicals with two hydroxyl groups which have a wide range of appealing applications as chemicals and fuels. In particular, four diol compounds, namely 1,3-propanediol (1,3-PDO), 1,2-propanediol (1,2-PDO), 2,3-butanediol (2,3-BDO) and 1,4-butanediol (1,4-BDO) can be biotechnologically produced by direct microbial bioconversion of renewable materials. These diols are considered as platform green chemicals. We review and discuss here the recent development in the microbial production of these diols, especially regarding the engineering of production strains and optimization of the fermentation processes.
二醇是一类含有两个羟基的化合物，在化学和燃料领域具有广泛的应用前景。特别地，有四种二醇化合物，即 1,3-丙二醇（1,3-PDO）、1,2-丙二醇（1,2-PDO）、2,3-丁二醇（2,3-BDO）和 1,4-丁二醇（1,4-BDO），可以通过可再生材料的直接微生物生物转化来生物合成。这些二醇被认为是平台绿色化学品。在这里，我们综述和讨论了这些二醇的微生物生产的最新进展，特别是关于生产菌株的工程改造和发酵工艺的优化。
