Department of Chemistry, Semnan University, Semnan, 2333383-193, Iran.
Department of Chemistry, Semnan University, Semnan, 2333383-193, Iran.
Chemosphere. 2022 Feb;289:133060. doi: 10.1016/j.chemosphere.2021.133060. Epub 2021 Nov 25.
Epirubicin (EP) and topotecan (TP) are two major anti-cancer compounds for the treatment of breast cancer with serious side effects. Hence herein, a carbon paste electrode (CPE) amplified with Pt/SWCNT nanocomposite and a deep eutectic solvent (CPE/DES/Pt-SWCNT) were proposed as an analytical tool for the monitoring of EP in the presence of TP in the real samples. Amplification of sensor was improve EP oxidation signal about 2.73 times. Under the optimized conditions, EP determined by using differential pulse voltammetry (DPV) technique with linear dynamic range of 0.001-500 μM with limit of detection (LOD) of 0.8 nM. The CPE/DES/Pt-SWCNT offered influential ability for monitoring of EP in injection and dextrose saline samples with a recovery range of 97.4%-104.9%.
表阿霉素（EP）和拓扑替康（TP）是两种用于治疗乳腺癌的主要抗癌化合物，具有严重的副作用。因此，本文提出了一种以碳糊电极（CPE）为基础，并通过 Pt/SWCNT 纳米复合材料放大的深共晶溶剂（CPE/DES/Pt-SWCNT），作为在实际样品中存在 TP 时监测 EP 的分析工具。传感器的放大提高了 EP 氧化信号约 2.73 倍。在优化条件下，采用差分脉冲伏安法（DPV）技术，EP 的线性动态范围为 0.001-500 μM，检测限（LOD）为 0.8 nM。CPE/DES/Pt-SWCNT 对注射液和葡萄糖生理盐水样品中的 EP 具有监测能力，回收率范围为 97.4%-104.9%。
