Palumbo Mariana Isa Poci, Resende Luiz Antonio de Lima, Olivo Giovane, de Oliveira-Filho José Paes, Borges Alexandre Secorun
Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Department of Neurology, Psychology and Psychiatry, College of Medicine - Univ Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.
J Equine Vet Sci. 2022 Jan;108:103783. doi: 10.1016/j.jevs.2021.103783. Epub 2021 Oct 7.
The visual evoked potential (VEP) has many applications in veterinary neurology, but the test is not routinely used in a clinical setting. The aim of this study was to describe a reliable method for recording flash visual evoked potentials (F-VEPs) in nonsedated horses. F-VEPs were recorded from both eyes in 20 healthy and calm, adult horses. Recordings were accomplished without sedation, anaesthesia, or the use of mydriatic drugs. The mean and standard deviation of the latency of the most evident positive peak was 52.76±2.37 ms (P53). The mean latencies of the preceding and following negative peaks were 38.14±4.62 (N38) and 72.35±5.33 ms (N72), respectively. There were 2 mean peak-to-peak amplitudes (N38 - P53 and P53 - N72), and they were 11.85±6.21 and 22.81±11.50 µV, respectively. F-VEP was also recorded from 3 horses (6 eyes) before and during sedation with 2 doses each of xylazine (0.4 and 1.1 mg/kg) or detomidine (0.005 and 0.014 mg/kg). It was possible to obtain a reliable F-VEP with a P53 latency in horses without sedation that was similar to the P2 peak described in previous studies, and these data can be used in the future as a normal reference for comparisons in horses with different diseases using a similar methodology. Sedation affected the results by depressing peak amplitudes and increasing latencies or by completely obscuring any response. The exact impact of sedation on VEPs must be evaluated with much caution due to the small sample size.
视觉诱发电位（VEP）在兽医神经病学中有许多应用，但该检测在临床环境中并非常规使用。本研究的目的是描述一种在未镇静马匹中记录闪光视觉诱发电位（F-VEP）的可靠方法。对20匹健康、安静的成年马的双眼进行了F-VEP记录。记录过程中未使用镇静剂、麻醉剂或散瞳药物。最明显正峰潜伏期的平均值和标准差为52.76±2.37毫秒（P53）。前一个和后一个负峰的平均潜伏期分别为38.14±4.62（N38）和72.35±5.33毫秒（N72）。有两个平均峰峰值幅度（N38 - P53和P53 - N72），分别为11.85±6.21和22.81±11.50微伏。还用赛拉嗪（0.�和1.1毫克/千克）或地托咪定（0.005和0.014毫克/千克）的两种剂量对3匹马（6只眼）在镇静前和镇静过程中进行了F-VEP记录。在未镇静的马匹中有可能获得潜伏期为P53的可靠F-VEP，这与先前研究中描述的P2峰相似，这些数据未来可作为使用类似方法对患有不同疾病马匹进行比较的正常参考。镇静会通过降低峰幅度和增加潜伏期或完全掩盖任何反应来影响结果。由于样本量小，必须非常谨慎地评估镇静对VEP的确切影响。
