Fatty Acid Research Institute, Sioux Falls, SD 57106, United States of America; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada; Division of Biochemical and Molecular Biology, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, United States of America.
Fatty Acid Research Institute, Sioux Falls, SD 57106, United States of America; Department of Population Health Nursing Science, College of Nursing, University of Illinois - Chicago, Chicago, IL 60612, United States of America.
Prostaglandins Leukot Essent Fatty Acids. 2022 Jan;176:102376. doi: 10.1016/j.plefa.2021.102376. Epub 2021 Nov 22.
Low red blood cell (RBC) membrane content of EPA and DHA, i.e., the omega-3 index (O3I), and elevated RBC distribution width (RDW) are risk factors for all-cause mortality. O3I and RDW are related with membrane fluidity and deformability. Our objective was to determine if there is a relationship between O3I and RDW in healthy adults. Subjects without inflammation or anemia, and with values for O3I, RDW, high-sensitivity C-reactive protein (CRP), body mass index (BMI), age and sex were identified (n = 25,485) from a clinical laboratory dataset of > 45,000 individuals. RDW was inversely associated with O3I in both sexes before and after (both p < 0.00001) adjusting models for sex, age, BMI and CRP. Stratification by sex revealed a sex-O3I interaction with the RDW-O3I slope (p < 0.00066) being especially steep in females with O3I ≤ 5.6%. In healthy adults of both sexes, the data suggested that an O3I of > 5.6% may help maintain normal RBC structural and functional integrity.
红细胞（RBC）中 EPA 和 DHA 含量低，即 ω-3 指数（O3I）升高，红细胞分布宽度（RDW）升高，是全因死亡率的危险因素。O3I 和 RDW 与膜流动性和变形性有关。我们的目的是确定健康成年人中 O3I 和 RDW 之间是否存在关系。在一个包含超过 45000 个人的临床实验室数据集中，我们确定了没有炎症或贫血，且 O3I、RDW、高敏 C 反应蛋白（CRP）、体重指数（BMI）、年龄和性别值都在正常范围内的受试者（n=25485）。在调整了性别、年龄、BMI 和 CRP 模型后，RDW 在两性中均与 O3I 呈负相关（均 p<0.00001）。按性别分层显示，性别-O3I 相互作用与 RDW-O3I 斜率相关（p<0.00066），O3I≤5.6%的女性尤其陡峭。在两性健康成年人中，数据表明 O3I>5.6%可能有助于维持正常 RBC 结构和功能的完整性。
