睡眠时长与睡眠时长年度变化与胃肠道癌症发病的关系：一项前瞻性队列研究。

Relationship of sleep duration and annual changes in sleep duration with the incidence of gastrointestinal cancers: a prospective cohort study.

机构信息

Cancer Foundation of China, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

出版信息

Chin Med J (Engl). 2021 Nov 24;134(24):2976-2984. doi: 10.1097/CM9.0000000000001770.

DOI:10.1097/CM9.0000000000001770

PMID:34839316

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8710321/

Abstract

BACKGROUND

Prospective analyses have yet to identify a consistent relationship between sleep duration and the incidence of gastrointestinal (GI) cancers. The effect of changes in sleep duration on GI cancer incidence has scarcely been studied. Therefore, we aimed to examine the association between baseline sleep duration and annual changes in sleep duration and GI cancer risk in a large population-based cohort study.

METHODS

A total of 123,495 participants with baseline information and 83,511 participants with annual changes in sleep duration information were prospectively observed from 2006 to 2015 for cancer incidence. Cox proportional-hazards models were used to calculate hazard ratios (HRs) and their confidence intervals (CIs) for GI cancers according to sleep duration and annual changes in sleep duration.

RESULTS

In baseline sleep duration analyses, short sleep duration (≤5 h) was significantly associated with a lower risk of GI cancer in females (HR: 0.31, 95% CI: 0.10-0.90), and a linear relationship between baseline sleep duration and GI cancer was observed (P = 0.010), especially in males and in the >50-year-old group. In the annual changes in sleep duration analyses, with stable category (0 to -15 min/year) as the control group, decreased sleep duration (≤-15 min/year) was significantly associated with the development of GI cancer (HR: 1.29; 95% CI: 1.04-1.61), especially in the >50-year-old group (HR: 1.32; 95% CI: 1.01-1.71), and increased sleep duration (>0 min/year) was significantly associated with GI cancer in females (HR: 2.89; 95% CI: 1.14-7.30).

CONCLUSIONS

Both sleep duration and annual changes in sleep duration were associated with the incidence of GI cancer.

摘要

背景

前瞻性分析尚未确定睡眠时间与胃肠道（GI）癌症发病率之间的一致关系。睡眠时间变化对 GI 癌症发病率的影响几乎没有研究过。因此，我们旨在通过一项大型基于人群的队列研究，检查基线睡眠时间和每年睡眠时间变化与 GI 癌症风险之间的关联。

方法

2006 年至 2015 年期间，共前瞻性观察了 123495 名有基线信息和 83511 名有每年睡眠时间变化信息的参与者的癌症发病率。使用 Cox 比例风险模型根据睡眠时间和每年睡眠时间变化计算 GI 癌症的风险比（HR）及其置信区间（CI）。

结果

在基线睡眠时间分析中，短睡眠时间（≤5 小时）与女性 GI 癌症风险降低显著相关（HR：0.31，95%CI：0.10-0.90），并且观察到基线睡眠时间与 GI 癌症之间存在线性关系（P=0.010），尤其是在男性和>50 岁的人群中。在每年睡眠时间变化的分析中，以稳定类别（0 至-15 分钟/年）作为对照组，睡眠时间减少（≤-15 分钟/年）与 GI 癌症的发生显著相关（HR：1.29；95%CI：1.04-1.61），尤其是在>50 岁的人群中（HR：1.32；95%CI：1.01-1.71），并且女性睡眠时间增加（>0 分钟/年）与 GI 癌症显著相关（HR：2.89；95%CI：1.14-7.30）。