Dept. of Neuroradiology, Medical Center - University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.
Dept. of Medical Physics, Medical Center - University of Freiburg, Freiburg, Germany.
Neuroradiology. 2022 Mar;64(3):443-452. doi: 10.1007/s00234-021-02865-x. Epub 2021 Nov 27.
Focal cortical dysplasia (FCD) are histopathologically categorized in ILAE type I to III. Mild malformations of cortical development (mMCD) including those with oligodendroglial hyperplasia (MOGHE) are to be integrated into this classification yet. Only FCD type II have distinctive MRI and molecular genetics alterations so far. Subtle FCD including FCD type II located in the depth of a sulcus are often overlooked requiring the use of dedicated sequences (MP2RAGE, FLAWS, EDGE) and/or voxel (VBM)- or surface-based (SBM) postprocessing. The added value of 7 Tesla MRI has to be proven yet.
局灶性皮质发育不良（FCD）在组织病理学上分为 ILAE 1 型至 3 型。轻度皮质发育不良（mMCD）包括少突胶质细胞增生（MOGHE），有待纳入该分类。到目前为止，只有 FCD 2 型具有独特的 MRI 和分子遗传学改变。位于沟深部的细微 FCD 包括 FCD 2 型，往往容易被忽视，需要使用专用序列（MP2RAGE、FLAWS、EDGE）和/或体素（VBM）或基于表面（SBM）的后处理。7 特斯拉 MRI 的附加值尚待证明。
