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多发性大动脉炎伴发恶性肿瘤的弥漫性冠状动脉受累。

Diffused coronary involvement in Takayasu arteritis with concomitant malignancy.

机构信息

Cardiology Division, Rabin Medical Center - Beilinson Hospital, 39 Zabotinski st., 4941492, Petach Tikva, Israel.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

出版信息

Clin Rheumatol. 2022 Mar;41(3):921-928. doi: 10.1007/s10067-021-06000-2. Epub 2021 Nov 27.

Abstract

Large vessel vasculitis (LVV) is composed of conditions in which inflammation of blood vessel walls affects mainly large arteries, such as the aorta and its main branches, and in some cases the coronary arteries. Coronary artery involvement in systemic vasculitis is associated with significant morbidity and mortality. We present a case of a young patient diagnosed with extensive coronary disease diagnosed as Takayasu arteritis, when whom a concomitant diagnosis of Hodgkin's lymphoma was made. The literature review revealed ten cases of malignancies associated with Takayasu arteritis. We discuss the complexity of the management of concurrent hematological malignancy with TAK and extensive coronary arteritis. This complicated and cross-disciplinary case also represents the pivotal importance of multi-disciplinary team decision in order to achieve the best clinical outcome of both disorders.

摘要

巨细胞动脉炎(LVV)由血管壁炎症主要影响大动脉(如主动脉及其主要分支)的疾病组成,在某些情况下还会影响冠状动脉。系统性血管炎累及冠状动脉与较高的发病率和死亡率相关。我们报告了一例年轻患者,被诊断为广泛的冠状动脉疾病,病因是 Takayasu 动脉炎,同时还诊断出霍奇金淋巴瘤。文献回顾显示,有 10 例恶性肿瘤与 Takayasu 动脉炎相关。我们讨论了并发血液系统恶性肿瘤与 TAK 和广泛冠状动脉炎的治疗的复杂性。这个复杂的跨学科病例也代表了多学科团队决策的重要性,以便为两种疾病都获得最佳的临床结果。

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