Department of Urology, Edirne Sultan 1st Murat State Hospital, Edirne.
Department of Urology, Gümüs¸hane State Hospital, Gümüs¸hane.
Arch Ital Urol Androl. 2021 Oct 1;93(3):361-365. doi: 10.4081/aiua.2021.3.361.
We aimed to analyze the trend change of the most popular Phosphodiesterase-5 Inhibitors (PDE5i) over time and geography by using Google Trends (GT) data in 10 years period and COVID-19 pandemic.
GT is able to generate a "line-graph", showing how interest has increased or decreased over a period within specific territories. The search values for specific terms are indexed as relative search volume (RSV), which is presented on a scale from 0-100. Avarage annual percentage change (AAPC) and RSV were analyzed to evaluate gain or loss of interest in trends. Search terms were generated for Food and Drug Administration (FDA)-approved PDE5i; tadalafil, sildenafil, vardenafil, avanafil, and their most-used brand names. The data was within "worldwide" from 1 January 2010, to 31 December 2020, using the ''global'' query category.
The overall interest in PDE5i has doubled. Sildenafil has become the most trend PDE5i of today with a regular increase (AAPC: 0.016, p < 0.01). Although the search trend of tadalafil remained almost constant until 2014, the rate of increase in the last 6 years raised and tadalafil has become the 2nd most popular PDE5i recently (AAPC: 0.007, p < 0.01). For vardenafil there has been a decreased interest (AAPC: -0.009, p < 0.01). There is no significant change in avanafil trend (AAPC: 0.000, p: 0.5). All PDE5i interest on GT decreased notably from February to June 2020. But after June, search trends reached the level before the COVID-19 period in a month.
These findings show us, with its increasing prevalence, erectile dysfunction (ED) has become a major public health problem. People from different geographies search the internet for ED treatment options. Patients should be informed that ED may be the first sign of many comorbid diseases, and patients with ED should be referred to a health institution for diagnosis and treatment.
我们旨在使用谷歌趋势（GT）数据，分析 10 年间和 COVID-19 大流行期间，最受欢迎的磷酸二酯酶 5 抑制剂（PDE5i）的趋势变化。
GT 能够生成一个“折线图”，显示在特定地区内一段时间内兴趣的增加或减少。特定术语的搜索值被索引为相对搜索量（RSV），以 0-100 的比例表示。分析平均年百分比变化（AAPC）和 RSV，以评估趋势中兴趣的增减。为食品和药物管理局（FDA）批准的 PDE5i 生成搜索词；他达拉非、西地那非、伐地那非、阿伐那非及其最常用的商品名。数据来自 2010 年 1 月 1 日至 2020 年 12 月 31 日期间，使用“全球”查询类别，来自“全球”。
对 PDE5i 的总体兴趣增加了一倍。西地那非已成为当今最受欢迎的 PDE5i，呈持续增长（AAPC：0.016，p<0.01）。尽管他达拉非的搜索趋势在 2014 年前几乎保持不变，但在过去 6 年中，增长率有所上升，他达拉非最近已成为第二大受欢迎的 PDE5i（AAPC：0.007，p<0.01）。伐地那非的兴趣有所下降（AAPC：-0.009，p<0.01）。阿伐那非的趋势没有明显变化（AAPC：0.000，p：0.5）。2020 年 2 月至 6 月期间，GT 上所有 PDE5i 的搜索量均明显下降。但 6 月之后，搜索趋势在一个月内达到了 COVID-19 之前的水平。
这些发现表明，随着 ED 的患病率不断上升，ED 已成为一个主要的公共卫生问题。来自不同地域的人们在互联网上搜索 ED 治疗选择。应告知患者，ED 可能是许多合并症的首发症状，ED 患者应转至医疗机构进行诊断和治疗。
