Ruel-Gagné Sophie, Simonyan David, Légaré Jean, Bessette Louis, Fortin Paul R, Lacaille Diane, Dogba Maman Joyce, Michou Laëtitia
Division of Rheumatology-R4774, Department of Medicine, CHU de Québec-Université Laval, 2705 Boulevard Laurier, Quebec, QC, G1V 4G2, Canada.
Centre de Recherche du CHU de Québec-Université Laval, Quebec, Canada.
BMC Rheumatol. 2021 Nov 29;5(1):52. doi: 10.1186/s41927-021-00222-2.
Precision medicine, as a personalized medicine approach based on biomarkers, is a booming field. In general, physicians and patients have a positive attitude toward precision medicine, but their knowledge and experience are limited. In this study, we aimed at assessing the expectations and educational needs for precision medicine among rheumatologists, rheumatology fellows and patients with rheumatic diseases in Canada.
We conducted two anonymous online surveys between June and August 2018, one with rheumatologists and fellows and one with patients assessing precision medicine expectations and educational needs. Descriptive statistics were performed.
45 rheumatologists, 6 fellows and 277 patients answered the survey. 78% of rheumatologists and fellows and 97.1% of patients would like to receive training on precision medicine. Most rheumatologists and fellows agreed that precision medicine tests are relevant to medical practice (73.5%) with benefits such as helping to determine prognosis (58.9%), diagnosis (79.4%) and avoid treatment toxicity (61.8%). They are less convinced of their usefulness in helping to choose the most effective treatment and to improve patient adherence (23.5%). Most patients were eager to take precision medicine tests that could predict disease prognosis (92.4%), treatment response (98.1%) or drug toxicity (93.4%), but they feared potential negative impacts like loss of insurability (62.2%) and high cost of the test (57.5%).
Our study showed that rheumatologists and patients in Canada are overall interested in getting additional precision medicine education. Indeed, while convinced of the potential benefits of precision medicine tests, most physicians don't feel confident in their abilities and consider their training insufficient to incorporate them into clinical practice.
精准医学作为一种基于生物标志物的个性化医疗方法，是一个蓬勃发展的领域。总体而言，医生和患者对精准医学持积极态度，但他们的知识和经验有限。在本研究中，我们旨在评估加拿大风湿病学家、风湿病专科住院医师和风湿病患者对精准医学的期望和教育需求。
我们在2018年6月至8月期间进行了两项匿名在线调查，一项针对风湿病学家和专科住院医师，另一项针对患者，以评估对精准医学的期望和教育需求。进行了描述性统计。
45名风湿病学家、6名专科住院医师和277名患者回答了调查。78%的风湿病学家和专科住院医师以及97.1%的患者希望接受精准医学培训。大多数风湿病学家和专科住院医师认为精准医学检测与医疗实践相关（73.5%），其益处包括有助于确定预后（58.9%）、诊断（79.4%）和避免治疗毒性（61.8%）。他们不太确信其在帮助选择最有效治疗方法和提高患者依从性方面的有用性（23.5%）。大多数患者渴望进行能够预测疾病预后（92.4%）、治疗反应（98.1%）或药物毒性（93.4%）的精准医学检测，但他们担心潜在的负面影响，如失去保险资格（62.2%）和检测成本高昂（57.5%）。
我们的研究表明，加拿大的风湿病学家和患者总体上有兴趣接受更多的精准医学教育。事实上，虽然确信精准医学检测的潜在益处，但大多数医生对自己的能力缺乏信心，并认为他们的培训不足以将其纳入临床实践。
