结节性红斑相关的肉芽肿性乳腺炎：42例病例系列
Granulomatous mastitis associated with erythema nodosum: A case series of 42 patients.
作者信息
Moreno-Vílchez Carlos, Llobera-Ris Clàudia, Penin Rosa María, Pla María Jesús, Mitjavila Francesca, Marcoval Joaquim
机构信息
Servicio de Dermatología, Hospital Universitari de Bellvitge, IDIBELL, Universidad de Barcelona, Hospitalet de Llobregat, Barcelona, España.
Servicio de Dermatología, Hospital Universitari de Bellvitge, IDIBELL, Universidad de Barcelona, Hospitalet de Llobregat, Barcelona, España.
出版信息
Med Clin (Barc). 2022 Mar 11;158(5):229-232. doi: 10.1016/j.medcli.2021.10.001. Epub 2021 Nov 25.
BACKGROUND
Granulomatous mastitis (GM) is defined by the formation of granulomatous inflammation in breast tissue. Erythema nodosum (EN) is a reactive inflammatory panniculitis characterized by erythematous subcutaneous nodules in the lower limbs. The association of GM with EN has been rarely reported. Our aim was to retrospectively review our series of patients with GM to better characterize their features and their association with EN.
METHODS
Cases histologically diagnosed as granulomatous inflammation in breast tissue between 1995 and 2020 were retrospectively reviewed.
RESULTS
Forty-two women were diagnosed with GM. The average age at diagnosis was 41.619years, and 59.5% were of South-American ethnicity. EN was associated with GM in 11.9% of the patients. Patients with EN were diagnosed earlier than isolated GM (0.4months vs 6.81months; P<.05). Ulceration in the GM was more prevalent in patients with associated EN (60% vs 14.7%; P<.05).
CONCLUSION
EN in patients with GM may reduce the evolution time and may help to diagnose this rare condition that mimics breast carcinoma.
背景
肉芽肿性乳腺炎（GM）是由乳腺组织中形成肉芽肿性炎症所定义的。结节性红斑（EN）是一种反应性炎症性脂膜炎，其特征为下肢出现红斑性皮下结节。GM与EN的关联鲜有报道。我们的目的是回顾性分析我们收治的一系列GM患者，以更好地描述其特征以及与EN的关联。
方法
回顾性分析1995年至2020年间组织学诊断为乳腺组织肉芽肿性炎症的病例。
结果
42名女性被诊断为GM。诊断时的平均年龄为41.619岁，59.5%为南美裔。11.9%的患者EN与GM相关。合并EN的患者比单纯GM患者诊断更早（0.4个月对6.81个月；P<0.05）。合并EN的GM患者溃疡更为常见（60%对14.7%；P<0.05）。
结论
GM患者中的EN可能会缩短病程，并有助于诊断这种易误诊为乳腺癌的罕见疾病。
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