Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P. R. China.
J Invest Surg. 2023 Sep 8;36(1):2257770. doi: 10.1080/08941939.2023.2257770. Epub 2023 Oct 24.
Granulomatous lobular mastitis (GLM) is a benign inflammatory disease of the mammary gland with unknown etiology. Erythema nodosum (EN) is a rare, extramammary symptom of GLM. The purpose of this article was to investigate the clinical features of EN associated with GLM.
We recruited 102 GLM patients diagnosed between December 2018 and December 2021 at Renmin Hospital of Wuhan University. The clinical characteristics and laboratory indices of the EN group ( = 12) and the non-EN group ( = 90) were compared.
The proportion of GLM patients with lesions involving ≥2 quadrants and high peripheral white blood cell count, absolute neutrophil count and neutrophil-to-lymphocyte ratio (NLR) was larger in the EN group than in the non-EN group ( = 0.002, 0.025, 0.014, 0.002, respectively). The duration of EN was longer in GLM patients with EN than in GLM patients without EN ( = 0.005). GLM patients with EN had more abscesses and sinus tracts than those without EN ( = 0.003, 0.038). Lesions involving ≥2 quadrants and the NLR were positively associated with the occurrence of EN ( = 0.304, 0.0302, = 0.002, 0.002). Receiver operating characteristic curve analysis revealed that the area under the curve of the NLR was 0.770. When NLR > 5.73, the sensitivity and specificity of predicting EN were 66.67% and 87.78%, respectively.
Our findings suggest that GLM concomitant with EN suggests the presence of a more severe condition and extensive lesions.
肉芽肿性小叶性乳腺炎（GLM）是一种病因不明的乳腺良性炎症性疾病。结节性红斑（EN）是 GLM 罕见的乳房外症状。本文旨在探讨与 GLM 相关的 EN 的临床特征。
我们招募了 2018 年 12 月至 2021 年 12 月在武汉大学人民医院诊断为 GLM 的 102 例患者。比较了 EN 组（ = 12）和非 EN 组（ = 90）的临床特征和实验室指标。
EN 组 GLM 患者病变累及≥2 象限、外周白细胞计数、绝对中性粒细胞计数和中性粒细胞与淋巴细胞比值（NLR）较高的比例大于非 EN 组（ = 0.002、0.025、0.014、0.002）。EN 组 GLM 患者的 EN 持续时间长于非 EN 组（ = 0.005）。EN 组 GLM 患者脓肿和窦道多于非 EN 组（ = 0.003、0.038）。病变累及≥2 象限和 NLR 与 EN 的发生呈正相关（ = 0.304、0.0302、 = 0.002、0.002）。受试者工作特征曲线分析显示，NLR 的曲线下面积为 0.770。当 NLR > 5.73 时，预测 EN 的敏感性和特异性分别为 66.67%和 87.78%。
我们的研究结果表明，GLM 伴发 EN 提示病情更严重，病变范围更广。
