Department of Burn and Wound Repair, Weifang People's Hospital, Weifang, Shandong, China.
Department of Burns and Plastic Surgery, Binzhou People's Hospital Binzhou, Shandong, China.
Comput Math Methods Med. 2021 Nov 18;2021:9785466. doi: 10.1155/2021/9785466. eCollection 2021.
Low-cost and safe strategies to improve wound healing will be of great social and economic value. The goal of this pilot clinical trial is aimed at analyzing how effective insulin therapy is at healing wounds in nondiabetic people.
In this protocol research, 346 individuals were included. Patients were divided as 2 groups at random: experimental patients were given a ten-unit answer. For each 10 cm of wound, insulin was injected in solution with 1 mL 0.9 percent saline, whereas the control group got a standard dressing with normal saline.
During the therapy period, no adverse effects were reported. After insulin therapy, no substantial insulin-related side effects were reduced. After 10 days of therapy, the experimental group's granulation tissue coverage rate and thickness were considerably improved as compared to control. Furthermore, a momentous difference in the occurrence of wound bleeding and suppurative wounds between the two groups ( = 0.05).
The results of this pilot research suggest that insulin injections could harmless and effective alternative therapy for wound healing in nondiabetic individuals and that larger, placebo-controlled trials are needed to evaluate effectiveness and safety of insulin treatment in wound healing patients.
寻找低成本且安全的方法来促进伤口愈合具有重要的社会和经济价值。本临床试验旨在分析胰岛素疗法对非糖尿病患者伤口愈合的效果。
本研究共纳入 346 例患者，将患者随机分为两组：实验组给予 10 个单位的胰岛素，每 10cm 的伤口用 1ml 浓度为 0.9%的生理盐水溶解胰岛素进行注射，对照组给予常规生理盐水换药。
治疗期间未出现不良反应。胰岛素治疗后，患者的伤口无明显胰岛素相关副作用。治疗 10 天后，实验组肉芽组织覆盖率和厚度明显优于对照组。此外，两组患者在伤口出血和化脓性伤口的发生率上存在显著差异（=0.05）。
本研究初步结果表明，胰岛素注射可能是非糖尿病患者伤口愈合的一种安全有效的替代治疗方法，但需要更大规模、安慰剂对照的临床试验来评估胰岛素治疗在伤口愈合患者中的有效性和安全性。
