Wang Jiao, Xu Jixiong
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Mar 13;13:719-727. doi: 10.2147/DMSO.S237294. eCollection 2020.
Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.
伤口愈合是一个复杂的生物学过程，可修复受损组织并恢复皮肤完整性。胰岛素是伤口愈合的一个重要因素，近一个世纪以来，大量人体和动物研究表明，它能促使各种伤口快速愈合。尽管许多研究探讨了全身性胰岛素对烧伤创面的愈合作用，但仅有少数研究调查了局部应用胰岛素的疗效。因此，本研究旨在综述局部应用胰岛素对伤口愈合（包括糖尿病和非糖尿病伤口）影响的证据。所展示的动物和临床研究支持局部应用胰岛素可通过多种机制改善伤口愈合且无副作用。此外，各种伤口敷料通过可控且持续地释放生物活性胰岛素来加速伤口愈合。因此，局部应用胰岛素在伤口愈合领域受到重视，还需要进一步研究以增进我们对胰岛素在各种伤口愈合中作用的理解。
