Brimo Alsaman Muhamad Zakaria, Shashaa Mohammad Nour, Alkarrash Mohamad Shadi, Kitaz Mohammad Nour, Zazo Aya, Alhamid Ahmad, Zazo Rama, Haj Kadour Samer
Faculty of Medicine, University of Aleppo, Aleppo, Syria.
MD. Pathology Department, Aleppo University Hospital, Aleppo, Syria.
Ann Med Surg (Lond). 2021 Nov 5;71:103015. doi: 10.1016/j.amsu.2021.103015. eCollection 2021 Nov.
Group A Streptococcus is a very common pathogen which infects a large scale of people around the world causing many symptoms such as scarlet fever, sinusitis, and pneumonia. Most strains of group A and many other strains of group C and G Streptococcus bacteria secreted antigen called Streptolysin O. Anti-streptolysin O (ASO) is an antibody produced against streptolysin O that rises after 1 week of infection by streptococcus bacteria, which helps in diagnosing this type of infectious diseases. We conducted a Cross-Sectional study to determine the Upper Limit of Normal (ULN) for healthy adult in Aleppo, Syria.
A sero-epidemiological cross-sectional study was conducted from September to October in 2019. ASO titers were determined on 267 healthy patients' companions who visited Aleppo University Hospital. Geometric mean titer and Upper Limit of Normal of ASO were calculated according to sex, age and residency. Upper Limit of Normal were defined as the 80th percentile.
Out of 267 participants; 126 (45.7%) were males and 150 (54.3) were females. The Upper Limit of Normal for total participants was 210.8 IU/ml. There was no significant difference (P-value > 0.05) among males (204.6 IU/ml) and females (225.8 IU/ml). In contrast to sex, there was a significant difference (P-value < 0.05) according to age groups, where the highest Upper Limit of Normal was in the 30-39 age group (256.0 IU/ml).
ASO test is a common, easy, cheap method, so getting enough data about it is very important in the developing countries (such as Syria). In Aleppo, Syria we found that the ULN was higher than ULN from other studies. There was no significant difference according to sex and residency. On the other hand, there was significant difference according to age groups.
A 组链球菌是一种非常常见的病原体，它感染了世界各地大量的人，会引发许多症状，如猩红热、鼻窦炎和肺炎。A 组的大多数菌株以及 C 组和 G 组链球菌的许多其他菌株会分泌一种名为链球菌溶血素 O 的抗原。抗链球菌溶血素 O（ASO）是一种针对链球菌溶血素 O 产生的抗体，在感染链球菌细菌 1 周后会升高，这有助于诊断这类传染病。我们进行了一项横断面研究，以确定叙利亚阿勒颇健康成年人的正常上限（ULN）。
2019 年 9 月至 10 月进行了一项血清流行病学横断面研究。对 267 名前往阿勒颇大学医院就诊的健康患者的同伴测定了 ASO 滴度。根据性别、年龄和居住地计算了 ASO 的几何平均滴度和正常上限。正常上限定义为第 80 百分位数。
在 267 名参与者中，126 名（45.7%）为男性，150 名（54.3%）为女性。所有参与者的正常上限为 210.8 IU/ml。男性（204.6 IU/ml）和女性（225.8 IU/ml）之间无显著差异（P 值>0.05）。与性别相反，根据年龄组存在显著差异（P 值<0.05），其中正常上限最高的是 30 - 39 岁年龄组（256.0 IU/ml）。
ASO 检测是一种常见、简便、廉价的方法，因此在发展中国家（如叙利亚）获取足够关于它的数据非常重要。在叙利亚阿勒颇，我们发现正常上限高于其他研究中的正常上限。根据性别和居住地无显著差异。另一方面，根据年龄组存在显著差异。
