Boskabadi Javad, Kargar-Soleiman Abad Saeed, Mehrpisheh Shahrokh, Pishavar Elham, Farhadi Roya
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ann Med Surg (Lond). 2021 Dec;72:103119. doi: 10.1016/j.amsu.2021.103119. Epub 2021 Nov 24.
and importance: Limited data are available about various effects of COVID-19 on pregnancy. On the other hand, the COVID-19 pandemic could exacerbate anxiety or schizophrenia symptoms.
The patient is a 5-day-old newborn, whom his mother suffers from schizophrenia, depression and anxiety disorders. The young pregnant mother gets delusions of being infected with Covid-19, thus attempts suicide with Sertraline, Clonazepam, Quetiapine and Rispeirdone, although she was in the last week of pregnancy. The newborn baby referred to our neonatal ward with seizure and apnea. Phenytoin and caffeine were administered leading to some degree of symptom relief, but due to the dermatologic reactions of phenytoin, they were replaced with levetiracetam.
The Covid-19 may increase levels of anxiety and depression or exacerbation of schizophrenia symptoms, especially in pregnant women suffering from mental disorders. In addition, there are evidence supporting the occurrence of neonatal malformations as a result of exposure to antipsychotic drugs during the first trimester of pregnancy.
Investigating the role of antidepressant and antipsychotic drugs in the perinatal period, especially near delivery has received less attention so far; thus further studies are required to determine the safety of these drugs.
及重要性：关于新冠病毒对妊娠的各种影响，现有数据有限。另一方面，新冠疫情可能会加剧焦虑或精神分裂症症状。
患者是一名5天大的新生儿，其母亲患有精神分裂症、抑郁症和焦虑症。这位年轻的孕妇出现感染新冠病毒的妄想，尽管已处于妊娠最后一周，但仍试图服用舍曲林、氯硝西泮、喹硫平和利培酮自杀。新生儿因癫痫发作和呼吸暂停被转诊至我们的新生儿病房。给予苯妥英钠和咖啡因后症状有一定程度缓解，但由于苯妥英钠的皮肤反应，改用左乙拉西坦。
新冠病毒可能会增加焦虑和抑郁水平，或加剧精神分裂症症状，尤其是在患有精神障碍的孕妇中。此外，有证据支持在妊娠头三个月接触抗精神病药物会导致新生儿畸形。
迄今为止，关于抗抑郁药和抗精神病药物在围产期尤其是临近分娩时的作用研究较少；因此需要进一步研究以确定这些药物的安全性。
