Wolff B E, Bearse M A, Schneck M E, Dhamdhere K, Harrison W W, Barez S, Adams A J
School of Optometry, University of California, Berkeley, Berkeley, CA, 94720-2020, USA,
Doc Ophthalmol. 2015 Apr;130(2):131-9. doi: 10.1007/s10633-014-9476-4. Epub 2014 Dec 17.
We investigate how type 2 diabetes (T2DM) and diabetic retinopathy (DR) affect color vision (CV) and mfERG implicit time (IT), whether CV and IT are correlated, and whether CV and IT abnormality classifications agree.
Adams desaturated D-15 color test, mfERG, and fundus photographs were examined in 37 controls, 22 T2DM patients without DR (NoRet group), and 25 T2DM patients with DR (Ret group). Color confusion score (CCS) was calculated. ITs were averaged within the central 7 hexagons (central IT; ≤4.5°) and outside this area (peripheral IT; ≥4.5°). DR was within (DRIN) or outside (DROUT) of the central 7 hexagons. Group differences, percentages of abnormalities, correlations, and agreement were determined.
CCS was greater in the NoRet (P = 0.002) and Ret (P < 0.0001) groups than in control group. CCS was abnormal in 3, 41, and 48 % of eyes in the control, NoRet, and Ret groups, respectively. Ret group CV abnormalities were more frequent in DRIN than in DROUT subgroups (71 vs. 18 %, respectively; P < 0.0001). CCS and IT were correlated only in the Ret group, in both retinal zones (P ≤ 0.028). Only in the Ret group did CCS and peripheral IT abnormality classifications agree (72 %; P < 0.05).
CV is affected in patients with T2DM, even without DR. Central DR increases the likelihood of a CV deficit compared with non-central DR. mfERG IT averaged across central or peripheral retinal locations is less frequently abnormal than CV in the absence of DR, and these two measures are correlated only when DR is present.
我们研究2型糖尿病（T2DM）和糖尿病视网膜病变（DR）如何影响色觉（CV）和多焦视网膜电图（mfERG）的隐含时间（IT），CV和IT是否相关，以及CV和IT异常分类是否一致。
对37名对照者、22名无DR的T2DM患者（无视网膜病变组）和25名有DR的T2DM患者（视网膜病变组）进行亚当斯去饱和D-15色觉测试、mfERG和眼底照相检查。计算颜色混淆评分（CCS）。在中央7个六边形区域内（中央IT；≤4.5°）和该区域外（周边IT；≥4.5°）对IT进行平均。DR位于中央7个六边形区域内（DRIN）或区域外（DROUT）。确定组间差异、异常百分比、相关性和一致性。
无视网膜病变组（P = 0.002）和视网膜病变组（P < 0.0001）的CCS高于对照组。对照组、无视网膜病变组和视网膜病变组分别有3%、41%和48%的眼睛CCS异常。视网膜病变组中，DRIN亚组CV异常比DROUT亚组更常见（分别为71%和18%；P < 0.0001）。CCS和IT仅在视网膜病变组的两个视网膜区域相关（P≤0.028）。仅在视网膜病变组中，CCS和周边IT异常分类一致（72%；P < 0.05）。
即使没有DR，T2DM患者的CV也会受到影响。与非中央DR相比，中央DR增加了CV缺陷的可能性。在没有DR的情况下，跨中央或周边视网膜位置平均的mfERG IT异常频率低于CV，并且这两种测量仅在存在DR时相关。
