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重新定义现代非骨水泥全膝关节置换术的适应证:>75 岁患者的临床结果和生存率。

Redefining Indications for Modern Cementless Total Knee Arthroplasty: Clinical Outcomes and Survivorship in Patients >75 Years Old.

机构信息

Rothman Orthopaedic Institute, Thomas Jefferson University, Philadelphia, PA.

出版信息

J Arthroplasty. 2022 Mar;37(3):476-481.e1. doi: 10.1016/j.arth.2021.11.031. Epub 2021 Nov 26.

Abstract

BACKGROUND

Most studies on cementless total knee arthroplasty (TKA) have excluded patients >75 years due to concerns that older patients have poorer bone mineral density and osteogenic activity. This study compared the midterm outcomes and survivorship of cemented and cementless TKA of the same modern design performed in patients >75 years.

METHODS

We identified a consecutive series of 120 primary cementless TKA performed in patients >75 years. Each case was propensity score matched 1:3 with 360 cemented TKA of the same modern design based on age, sex, body mass index, Charlson Comorbidity Index, bilateral procedures, liner type, and year of surgery. Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR) and Short Form-12 (SF-12) were collected preoperatively, at 6 months and 2 years. Implant survivorship was recorded at mean 4.2 years (range, 2.0-7.9).

RESULTS

Mean age was 79.0 ± 3.4 years (range, 75-92) in the cemented cohort and 78.9 ± 3.5 (range, 75-91) in the cementless cohort (P = .769). There was no difference in final postoperative scores or improvement in scores at 2 years. The percentage of patients that met the minimal clinically important difference was also similar (KOOS-JR, 68.9% vs 69.2%, P = .955; SF-12 Physical, 71.7% vs 66.7%, P = .299). Seven-year survivorship free from aseptic revision was 99.4% for cemented knees and 100% for cementless knees (log-rank, P = .453).

CONCLUSION

Patients over 75 years undergoing cementless or cemented TKA of the same modern design had comparable outcomes and survivorship in the midterm. The theoretical risks of cementless fixation in this age group were not realized in this study.

摘要

背景

大多数关于非骨水泥全膝关节置换术(TKA)的研究都排除了>75 岁的患者,因为担心老年患者的骨密度和成骨活性较差。本研究比较了同一现代设计的骨水泥固定和非骨水泥固定 TKA 在>75 岁患者中的中期结果和存活率。

方法

我们确定了 120 例连续的>75 岁患者行非骨水泥 TKA。根据年龄、性别、体重指数、Charlson 合并症指数、双侧手术、衬垫类型和手术年份,对每例患者进行倾向评分 1:3 匹配,共匹配了 360 例同一现代设计的骨水泥 TKA。术前、术后 6 个月和 2 年采集膝关节损伤和骨关节炎评分(KOOS-JR)和健康调查简表 12 项(SF-12)。平均随访 4.2 年(范围 2.0-7.9)时记录假体存活率。

结果

骨水泥组平均年龄为 79.0±3.4 岁(范围 75-92),非骨水泥组为 78.9±3.5 岁(范围 75-91)(P=0.769)。两组最终术后评分和 2 年时评分改善均无差异。达到最小临床重要差异的患者比例也相似(KOOS-JR,68.9% vs 69.2%,P=0.955;SF-12 生理,71.7% vs 66.7%,P=0.299)。骨水泥固定膝关节和非骨水泥固定膝关节 7 年无无菌性翻修的存活率分别为 99.4%和 100%(对数秩检验,P=0.453)。

结论

同一现代设计的非骨水泥或骨水泥 TKA 治疗>75 岁患者的中期结果和存活率相当。在本研究中,该年龄组非骨水泥固定的理论风险并未成为现实。

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