Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia; Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, Saint Petersburg, Russia.
Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, Russia.
Nanomedicine. 2022 Feb;40:102500. doi: 10.1016/j.nano.2021.102500. Epub 2021 Nov 26.
Functionalization of the fullerene core with amino acids has become a new and promising direction in the field of nanochemistry. The biologic activity of water-soluble fullerene derivatives is based on such properties as lipophilicity, electron deficiency and photosensitivity. The complex of above-mentioned properties can be used to develop protection of biomolecules (in particular, proteins) from external physical and chemical influences. Thus, development and up-scaling of synthesis procedures, as well as investigation of the biological properties of these derivatives, are extremely important. This paper presents new data on the biocompatibility studies of C fullerene adduct with L-methionine (C[CHNOS]; C-Met). Antiradical activity, binding to human serum albumin (HSA), collagen and deoxyribonucleic acid (DNA), hemocompatibility, photodynamic properties, genotoxicity and cytotoxicity were studied. In addition, it was found that C-Met increases the photostability of the collagen molecule, and this effect is dose-dependent.
富勒烯核心的氨基酸功能化已经成为纳米化学领域的一个新的有前途的方向。水溶性富勒烯衍生物的生物活性基于疏水性、电子缺乏和光敏感性等性质。上述性质的复合物可用于开发保护生物分子（特别是蛋白质）免受外部物理和化学影响。因此，开发和扩大这些衍生物的合成工艺的规模，以及研究它们的生物学特性，是极其重要的。本文介绍了关于 L-蛋氨酸（C[CHNOS]；C-Met）与 C fullerene 加成物的生物相容性研究的新数据。研究了其抗自由基活性、与人血清白蛋白（HSA）、胶原蛋白和脱氧核糖核酸（DNA）的结合、血液相容性、光动力特性、遗传毒性和细胞毒性。此外，还发现 C-Met 增加了胶原蛋白分子的光稳定性，并且这种效果是剂量依赖性的。
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