Department of Clinical Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Department of Exercise and Physiology, University of Mohaghegh Ardabili, Ardabil, Iran.
Nutrition. 2022 Feb;94:111506. doi: 10.1016/j.nut.2021.111506. Epub 2021 Oct 3.
Glutamine can be beneficial to athletes for its antiinflammatory and antioxidant effects. The present study was designed to investigate the effect of glutamine supplementation on some atherosclerosis markers after exhaustive exercise in young healthy males.
In an intervention study, 30 healthy males (case = 15 and control = 15) were randomly assigned into two groups. For 14 d, the intervention group received 0.3 g of glutamine per kilogram of body weight per day, with 25 g of sugar in 250 mL of water, and the control group received 25 g of sugar per 250 mL of water. At the end of the intervention, the participants completed one session of exhaustive exercise, and then fasting blood samples were taken to test serum levels of atherosclerosis markers.
In the intervention group, the serum levels of leptin, cholesterol, and oxidized low-density lipoprotein were lower than in the control group after 2 wk of glutamine supplementation (P < 0.05). Interleukin-6 serum levels were lower in the intervention group compared to the control group after supplementation, but not significantly. Serum levels of leptin, interleukin-6, cholesterol, and oxidized low-density lipoprotein, as well as the ratio of oxidized low-density lipoprotein to high-density lipoprotein, were significantly decreased in the intervention group compared to the control group after exhaustive exercise (P < 0.05).
Glutamine supplementation has beneficial effects for athletes, particularly those doing strenuous physical exercise, through reducing atherosclerosis-related biomarkers and elevating serum adiponectin levels, and it can potentially play a role in decreasing the initiation and progression of atherosclerosis.
谷氨酰胺具有抗炎和抗氧化作用，因此可能对运动员有益。本研究旨在探讨补充谷氨酰胺对年轻健康男性剧烈运动后某些动脉粥样硬化标志物的影响。
在一项干预研究中，将 30 名健康男性（病例组 15 名，对照组 15 名）随机分为两组。干预组连续 14 天每天接受 0.3 克/千克体重的谷氨酰胺，与 25 克糖混合在 250 毫升水中，对照组接受 25 克糖/250 毫升水。干预结束时，所有参与者完成一次剧烈运动，然后抽取空腹血样检测动脉粥样硬化标志物的血清水平。
补充谷氨酰胺 2 周后，干预组的血清瘦素、胆固醇和氧化型低密度脂蛋白水平低于对照组（P<0.05）。补充后，干预组的血清白细胞介素-6 水平低于对照组，但差异无统计学意义。与对照组相比，剧烈运动后，干预组的血清瘦素、白细胞介素-6、胆固醇和氧化型低密度脂蛋白水平以及氧化型低密度脂蛋白与高密度脂蛋白的比值均显著降低（P<0.05）。
谷氨酰胺补充对运动员有益，特别是对进行剧烈体育锻炼的运动员有益，可通过降低与动脉粥样硬化相关的生物标志物和提高血清脂联素水平来发挥作用，可能有助于减少动脉粥样硬化的发生和进展。
