Mazani Mohammad, Fard Ali Shadman, Baghi Abbas Naghizadeh, Nemati Ali, Mogadam Reza Alipanah
J Pak Med Assoc. 2014 Jul;64(7):785-90.
To evaluate the efficacy of pomegranate juice supplementation on matrix metalloproteinases2 and 9 serum levels and improving antioxidant function in young healthy males during exhaustive exercise.
The study was conducted at Ardabil University of Medical Sciences, Iran, in 2010-11 and comprised 28 healthy subjects in 18-24 age bracket. They were randomly divided into control and supplemented groups. One cup of pomegranate juice and one cup of tap water were given to supplemented and control groups daily for two weeks respectively. Fasting blood samples were taken at baseline and at the end of two weeks of intervention. The subjects were given one exhaustive exercise and then fasting blood samples were taken for testing blood glutathione peroxidase and superoxide dismutase and serum levels of high sensitivity C-reactive protein, zinc, ceruloplasmin, matrix metalloproteinases 2 and 9, malondialdehyde and total antioxidant capacity. Data was analysed using descriptive statistical tests, paired and independent sample t-test.
The blood levels of glutathione peroxidase and superoxide dismutase and serum levels of total antioxidant capacity after exhaustive exercise in the supplemented group were significantly increased (p < 0.05), while the content of matrix metalloproteinases 2 and 9, ceruloplasmin and malondialdehyde showed a significant decrease in comparison to the control group (p < 0.05). Besides, there were no significant changes in other biochemical factors.
Regular intake of pomegranate juice significantly modulates matrix metalloproteinases 2 and 9and serum levels of some inflammatory factors and thus protects against exhaustive exercise-induced oxidative injury in young healthy males.
评估补充石榴汁对年轻健康男性在力竭运动期间基质金属蛋白酶2和9血清水平以及改善抗氧化功能的效果。
该研究于2010 - 11年在伊朗阿尔达比勒医科大学进行，纳入了28名年龄在18 - 24岁的健康受试者。他们被随机分为对照组和补充组。补充组和对照组每天分别饮用一杯石榴汁和一杯自来水，持续两周。在基线和干预两周结束时采集空腹血样。让受试者进行一次力竭运动，然后采集空腹血样以检测血液中的谷胱甘肽过氧化物酶、超氧化物歧化酶以及高敏C反应蛋白、锌、铜蓝蛋白、基质金属蛋白酶2和9、丙二醛的血清水平和总抗氧化能力。使用描述性统计检验、配对和独立样本t检验对数据进行分析。
补充组在力竭运动后血液中的谷胱甘肽过氧化物酶和超氧化物歧化酶水平以及血清总抗氧化能力显著升高（p < 0.05），而与对照组相比，基质金属蛋白酶2和9、铜蓝蛋白和丙二醛的含量显著降低（p < 0.05）。此外，其他生化因子无显著变化。
定期摄入石榴汁可显著调节基质金属蛋白酶2和9以及一些炎症因子的血清水平，从而保护年轻健康男性免受力竭运动诱导的氧化损伤。
