Cardiff Metropolitan University, Cardiff, United Kingdom.
Adv Genet. 2021;108:277-340. doi: 10.1016/bs.adgen.2021.08.005. Epub 2021 Oct 28.
The prevalence of non-communicable diseases has been on an upward trajectory for some time and this puts an enormous burden on the healthcare expenditure. Lifestyle modifications including dietary interventions hold an immense promise to manage and prevent these diseases. Recent advances in genomic research provide evidence that focussing these efforts on individual variations in abilities to metabolize nutrients (nutrigenetics) and exploring the role of dietary compounds on gene expression (nutrigenomics and nutri-epigenomics) can lead to more meaningful personalized dietary strategies to promote optimal health. This chapter aims to provide examples on these gene-diet interactions at multiple levels to support the need of embedding targeted dietary interventions as a way forward to prevent, avoid and manage diseases.
一段时间以来，非传染性疾病的患病率一直在上升，这给医疗保健支出带来了巨大的负担。生活方式的改变，包括饮食干预，为管理和预防这些疾病提供了巨大的希望。最近的基因组研究进展提供了证据，即把这些努力集中在个体对营养物质代谢能力的个体差异上（营养遗传学），并探索饮食化合物对基因表达的作用（营养基因组学和营养表观基因组学），可以制定更有意义的个性化饮食策略，促进最佳健康。本章旨在提供多个层面上的这些基因-饮食相互作用的例子，以支持将有针对性的饮食干预作为预防、避免和管理疾病的一种方法。
