a Department of Biochemistry and Molecular Biology-A , University of Murcia , Murcia , Spain.
b Department of Surgery, Hospital de la Vega Lorenzo Guirao , University of Murcia , Murcia , Spain.
Crit Rev Food Sci Nutr. 2018;58(17):3030-3041. doi: 10.1080/10408398.2017.1349731. Epub 2017 Aug 24.
Over time, the relationship between diet and health has aroused great interest, since nutrition can prevent and treat several diseases. It has been demonstrated that general recommendations on macronutrients and micronutrients do not affect to every individual in the same way because diet is an important environmental factor that interacts with genes. Thus, there is a growing necessity of improving a personalized nutrition to treat obesity and associated medical conditions, taking into account the interactions between diet, genes and health. Therefore, the knowledge of the interactions between the genome and nutrients at the molecular level, has led to the advent of nutritional genomics, which involves the sciences of nutrigenomics and nutrigenetics. In this review, we will comprehensively analyze the role of the most important genes associated with two interrelated chronic medical conditions, such as obesity and cardiovascular diseases.
随着时间的推移，饮食与健康之间的关系引起了极大的兴趣，因为营养可以预防和治疗多种疾病。已经证明，关于宏量营养素和微量营养素的一般建议并不能以同样的方式影响每个人，因为饮食是一个重要的环境因素，它与基因相互作用。因此，人们越来越需要改善个性化营养，以治疗肥胖症和相关的医疗条件，同时考虑到饮食、基因和健康之间的相互作用。因此，对基因组和营养物质在分子水平上相互作用的了解，导致了营养基因组学的出现，它涉及营养基因组学和营养遗传学。在这篇综述中，我们将全面分析与两种相互关联的慢性疾病（如肥胖症和心血管疾病）相关的最重要基因的作用。
