三种新的 Carabrane 倍半萜类衍生物来自于飞廉属植物全草。
Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.
机构信息
Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
Chin J Nat Med. 2021 Nov;19(11):868-873. doi: 10.1016/S1875-5364(21)60091-2.
Dicarabrols B and C (1 and 2), two new carabrane sesquiterpenoid dimers, along with one new carabrane sesquiterpenoid (3) were isolated from the whole plant of Carpesium abrotanoides L. Their full structures were established by extensive analysis of HR-ESI-MS and NMR spectroscopic data, and time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. Dicarabrol B possesses a novel C skeleton featuring a methylene-tethered bridge between two sesquiterpene moieties, while dicarabrol C presents the unique linkage of a cyclopentane ring in the molecule. Dicarabrol C exhibited potent inhibitory effects on HL-60 cells with an IC value of 3.7 μmol·L.
二卡波醇 B 和 C（1 和 2），两个新的卡波烷倍半萜二聚体，以及一个新的卡波烷倍半萜（3）从飞蓬全草中分离得到。通过 HR-ESI-MS 和 NMR 光谱数据分析以及时变密度泛函理论（TDDFT）电子圆二色性（ECD）计算，确定了它们的完整结构。二卡波醇 B 具有新颖的 C 骨架，在两个倍半萜部分之间具有亚甲基桥，而二卡波醇 C 则呈现分子中环戊烷环的独特连接。二卡波醇 C 对 HL-60 细胞表现出强烈的抑制作用，IC 值为 3.7 μmol·L。
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