Department of Neonatology, Kunshan Maternity and Children's Health Care Hospital, Kunshan, Jiangsu.
Department of Neonatology, Hainan Women and Children's Medical Center, Haikou, Hainan.
Ultrasound Q. 2021 Nov 30;38(1):43-48. doi: 10.1097/RUQ.0000000000000582.
Preterm infants are at risk of neurological impairments and long-term developmental delay. Head ultrasound (HUS) is a promising tool for early detection of preterm brain injury and prediction of neurodevelopmental outcomes. We performed a retrospective analysis of data of 42 preterm infants with neurodevelopmental follow-up at 12 to 24 months corrected age. Corpus callosum length (CC length) and corpus callosum-fastigium length (CCF length) were measured on the HUS scans. Motor function and communication skills were assessed using evaluation scales. Corpus callosum length and CCF length were correlated with neurodevelopmental outcomes using Spearman correlation analysis. Neither CC length nor CCF length correlated with motor developmental outcomes. On early HUS, the CCF length was negatively correlated with symbolic composite percentile ranks (Spearman ρ = -0.49, P = 0.033) and total percentile ranks (Spearman ρ = -0.545, P = 0.016). On follow-up HUS scans, the CCF length was also found to be negatively correlated with social composite raw scores and percentile ranks (Spearman ρ = -0.615, P = 0.005; and Spearman ρ = -0.64, P = 0.003, respectively), symbolic composite raw scores and percentile ranks (Spearman ρ = -0.609, P = 0.006; and Spearman ρ = -0.657, P = 0.002, respectively) and total raw scores and percentile ranks (Spearman ρ = -0.472, P = 0.041; and Spearman ρ = -0.504, P = 0.028, respectively). Corpus callosum-fastigium length measurement on serial HUS is useful in predicting cognitive and behavioral outcomes at corrected age 12 to 24 months.
早产儿存在神经功能障碍和长期发育迟缓的风险。头部超声（HUS）是一种有前途的工具，可用于早期检测早产儿脑损伤并预测神经发育结局。我们对 42 名有神经发育随访的早产儿进行了回顾性数据分析，随访时间为校正后 12 至 24 个月。在 HUS 扫描中测量胼胝体长度（CC 长度）和胼胝体-穹窿长度（CCF 长度）。使用评估量表评估运动功能和沟通技能。使用 Spearman 相关分析将胼胝体长度和 CCF 长度与神经发育结局进行相关性分析。CC 长度和 CCF 长度均与运动发育结局无相关性。在早期 HUS 中，CCF 长度与象征性综合百分位等级（Spearman ρ=-0.49，P=0.033）和总百分位等级（Spearman ρ=-0.545，P=0.016）呈负相关。在后续 HUS 扫描中，CCF 长度也与社会综合原始分数和百分位等级（Spearman ρ=-0.615，P=0.005；和 Spearman ρ=-0.64，P=0.003）、象征性综合原始分数和百分位等级（Spearman ρ=-0.609，P=0.006；和 Spearman ρ=-0.657，P=0.002）以及总原始分数和百分位等级（Spearman ρ=-0.472，P=0.041；和 Spearman ρ=-0.504，P=0.028）呈负相关。连续 HUS 上的 CCF 长度测量有助于预测校正后 12 至 24 个月的认知和行为结局。
