WECARE研究中与对侧乳腺癌相关的乳腺X线纹理特征。
Mammographic texture features associated with contralateral breast cancer in the WECARE Study.
作者信息
Watt Gordon P, Knight Julia A, Lin Christine, Lynch Charles F, Malone Kathleen E, John Esther M, Bernstein Leslie, Brooks Jennifer D, Reiner Anne S, Liang Xiaolin, Woods Meghan, Nguyen Tuong L, Hopper John L, Pike Malcolm C, Bernstein Jonine L
机构信息
Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
出版信息
NPJ Breast Cancer. 2021 Nov 29;7(1):146. doi: 10.1038/s41523-021-00354-1.
To evaluate whether mammographic texture features were associated with second primary contralateral breast cancer (CBC) risk, we created a "texture risk score" using pre-treatment mammograms in a case-control study of 212 women with CBC and 223 controls with unilateral breast cancer. The texture risk score was associated with CBC (odds per adjusted standard deviation = 1.25, 95% CI 1.01-1.56) after adjustment for mammographic percent density and confounders. These results support the potential of texture features for CBC risk assessment of breast cancer survivors.
为了评估乳腺钼靶纹理特征是否与对侧第二原发性乳腺癌（CBC）风险相关，我们在一项针对212例CBC女性患者和223例单侧乳腺癌对照者的病例对照研究中，使用治疗前乳腺钼靶片创建了一个“纹理风险评分”。在对乳腺钼靶密度百分比和混杂因素进行校正后，纹理风险评分与CBC相关（每校正标准差的比值比=1.25，95%可信区间1.01-1.56）。这些结果支持了纹理特征在乳腺癌幸存者CBC风险评估中的潜力。
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