Koike Shinsuke, Fujioka Mao, Satomura Yoshihiro, Koshiyama Daisuke, Tada Mariko, Sakakibara Eisuke, Okada Naohiro, Takano Yosuke, Iwashiro Norichika, Natsubori Tatsunobu, Zhu Yinghan, Abe Osamu, Kirihara Kenji, Yamasue Hidenori, Kasai Kiyoto
University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), Meguro-ku, Tokyo, 153-8902, Japan.
Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Meguro-ku, Tokyo, 153-8902, Japan.
NPJ Schizophr. 2021 Nov 29;7(1):56. doi: 10.1038/s41537-021-00186-9.
Many studies have tested the relationship between demographic, clinical, and psychobiological measurements and clinical outcomes in ultra-high risk for psychosis (UHR) and first-episode psychosis (FEP). However, no study has investigated the relationship between multi-modal measurements and long-term outcomes for >2 years. Thirty-eight individuals with UHR and 29 patients with FEP were measured using one or more modalities (cognitive battery, electrophysiological response, structural magnetic resonance imaging, and functional near-infrared spectroscopy). We explored the characteristics associated with 13- and 28-month clinical outcomes. In UHR, the cortical surface area in the left orbital part of the inferior frontal gyrus was negatively associated with 13-month disorganized symptoms. In FEP, the cortical surface area in the left insula was positively associated with 28-month global social function. The left inferior frontal gyrus and insula are well-known structural brain characteristics in schizophrenia, and future studies on the pathological mechanism of structural alteration would provide a clearer understanding of the disease.
许多研究检验了人口统计学、临床及心理生物学测量指标与精神病超高风险（UHR）及首发精神病（FEP）临床结局之间的关系。然而，尚无研究调查多模态测量指标与超过2年的长期结局之间的关系。对38名UHR个体和29名FEP患者使用了一种或多种测量方式（认知成套测验、电生理反应、结构磁共振成像和功能近红外光谱）进行测量。我们探究了与13个月和28个月临床结局相关的特征。在UHR组中，额下回左侧眶部的皮质表面积与13个月时的紊乱症状呈负相关。在FEP组中，左侧岛叶的皮质表面积与28个月时的整体社会功能呈正相关。左侧额下回和岛叶是精神分裂症中众所周知的脑结构特征，未来关于结构改变病理机制的研究将有助于更清晰地理解该疾病。
