Maceri D R, Sullivan M J, McClatchney K D
Laryngoscope. 1986 Jan;96(1):82-6. doi: 10.1288/00005537-198601000-00015.
Autoimmune thyroiditis (Hashimoto's disease) is one of a myriad of clinical entities associated with the endocrine system. The disease is thought to be a defect in the immune regulatory system. The following report is a study of 112 cases of Hashimoto's thyroiditis treated over a 10-year period. The incidence of malignancy associated with autoimmune thyroiditis in this study was 6.3%, which correlates well with the incidence of thyroid cancer seen in the general population at autopsy. We have concluded from this study that patients with autoimmune thyroid endocrinopathy are at no greater risk for the development of thyroid malignancy than the general population. A review of the pathophysiology of autoimmune disorders is discussed and recommendations for treatment of patients with Hashimoto's disease is provided.
自身免疫性甲状腺炎（桥本氏病）是与内分泌系统相关的众多临床病症之一。该疾病被认为是免疫调节系统的一种缺陷。以下报告是对10年间治疗的112例桥本氏甲状腺炎病例的研究。本研究中与自身免疫性甲状腺炎相关的恶性肿瘤发生率为6.3%，这与尸检时普通人群中甲状腺癌的发生率密切相关。我们从这项研究中得出结论，自身免疫性甲状腺内分泌病患者发生甲状腺恶性肿瘤的风险并不高于普通人群。本文讨论了自身免疫性疾病的病理生理学，并提供了桥本氏病患者的治疗建议。
