Post Graduate Nutrition Program, Faculty of Nutrition, Federal University of Alagoas, Maceió, Brazil.
Laboratory of Applied Sports Science, Institute of Physical Education and Sports, Federal University of Alagoas, Maceió, Brazil.
Crit Rev Food Sci Nutr. 2023;63(20):4785-4798. doi: 10.1080/10408398.2021.2007470. Epub 2021 Nov 30.
Creatine (CRE) and caffeine (CAF) have been used as ergogenic aids to improve exercise performance. The present study reviewed the current evidence supporting the additional use of CAF intake during or after the CRE loading on exercise performance. The search was carried out in eight databases, with the methodological quality of the studies assessed via the QualSyst tool. From ten studies that met the criteria for inclusion, six had strong, three moderate, and one weak methodological quality. CAF was ingested ∼1 h before the performance trial (5-7 mg.kg) after a CRE loading period (5-6 days with 0.3 g.kg.d) in five studies, with the combination CAF + CRE providing additional ergogenic effect compared to CRE alone in three of these studies. Furthermore, CAF was ingested daily during the CRE loading protocol in five studies, with CAF showing additive benefits compared to CRE alone only in one study (3 g.d of CRE during 3 days + 6 mg.kg of CAF for 3 days). The combination CAF + CRE seems to provide additional benefits to exercise performance when CAF is acutely ingested after a CRE loading. There is, however, no apparent benefit in ingesting CAF during a CRE loading period.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2021.2007470.
肌酸（CRE）和咖啡因（CAF）已被用作运动表现的增强剂，以提高运动表现。本研究综述了目前支持在 CRE 负荷期间或之后额外摄入 CAF 以提高运动表现的证据。搜索在八个数据库中进行，使用 QualSyst 工具评估研究的方法学质量。从符合纳入标准的十项研究中，六项具有强方法学质量，三项具有中等方法学质量，一项具有弱方法学质量。在五项研究中，CAF 在 CRE 负荷期（5-6 天，0.3 g.kg.d）后约 1 小时内（5-7 mg.kg）摄入，与 CRE 单独使用相比，组合 CAF+CRE 在其中三项研究中提供了额外的增强作用。此外，在五项研究中，CAF 在 CRE 负荷方案期间每天摄入，与 CRE 单独使用相比，仅在一项研究中显示出 CAF 的附加益处（3 天内每天 3 g CRE+3 天内每天 6 mg.kg CAF）。当 CAF 在 CRE 负荷后急性摄入时，CAF+CRE 的组合似乎对运动表现提供了额外的益处。然而，在 CRE 负荷期间摄入 CAF 并没有明显的益处。本文的补充数据可在 https://doi.org/10.1080/10408398.2021.2007470 在线获取。
