Nowell P C, Vonderheid E C, Besa E, Hoxie J A, Moreau L, Finan J B
Cancer Genet Cytogenet. 1986 Jan 15;19(3-4):219-27. doi: 10.1016/0165-4608(86)90050-6.
Among 46 patients with chronic lymphocytic leukemia (CLL) (40 B cell, 6 T cell) and 40 patients with cutaneous T cell lymphoma (CTCL), a chromosomally abnormal neoplastic clone was identified in 43 cases. A translocation involving 14q32 was present in nine cases (five B-CLL, two T-CLL, two CTCL). The donor chromosomal site was 11q13 in four patients and 1q12, 4q25-27, 17q21-22, 18q21, and 22q11 in one case each. The next most frequent abnormalities were rearrangements involving 6q21-23 (four cases), and trisomy 12 (four cases, all B-CLL). In one CTCL patient, the t(11;14) translocation was present in one of three apparently unrelated T cell clones. Recent studies indicate that the selective advantage conferred by the 14q+ chromosome in B cell neoplasms appears to result from an oncogene being brought adjacent to a rearranged and transcriptionally active immunoglobulin heavy chain locus. The present findings suggest that similar mechanisms may operate in certain T cell neoplasms, although the activating gene is not necessarily the same.
在46例慢性淋巴细胞白血病（CLL）患者（40例B细胞型，6例T细胞型）和40例皮肤T细胞淋巴瘤（CTCL）患者中，43例检测到染色体异常的肿瘤克隆。9例患者存在涉及14q32的易位（5例B - CLL、2例T - CLL、2例CTCL）。4例患者的供体染色体位点为11q13，各有1例患者的供体染色体位点为1q12、4q25 - 27、17q21 - 22、18q21和22q11。其次最常见的异常是涉及6q21 - 23的重排（4例）和三体12（4例，均为B - CLL）。在1例CTCL患者中，t(11;14)易位存在于三个明显不相关的T细胞克隆之一中。最近的研究表明，14q +染色体在B细胞肿瘤中赋予的选择优势似乎是由于一个癌基因与重排且转录活跃的免疫球蛋白重链基因座相邻。目前的研究结果表明，类似的机制可能在某些T细胞肿瘤中起作用，尽管激活基因不一定相同。
