Yang Minggang, Qiu Shi, Coy Emerson, Li Shuaijie, Załęski Karol, Zhang Yao, Pan Haobo, Wang Guocheng
Research Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong, 518055, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Adv Mater. 2022 Feb;34(6):e2106314. doi: 10.1002/adma.202106314. Epub 2021 Dec 26.
Implant-related microbial infection is a challenging clinical problem, and its treatment requires efficient eradication of the biofilm from the implant surface. Near-infrared (NIR)-responsive strategies are proposed as an emerging efficient antibacterial therapy. However, the utilization of photosensitizers or photocatalytic/photothermal nanomaterials in the available approach likely induces high potential risks of interfacial deterioration and biosafety compromise. Herein, a TiO /TiO metasurface with potent NIR-responsive antibacterial activity is produced on a Ti alloy implant by a newly invented topochemical conversion-based alkaline-acid bidirectional hydrothermal method (aaBH). Electromagnetic simulations prove that NIR absorption and near-field distribution of the metasurface can be tuned by the dimension and arrangement of the nanostructural unit. Promising antibacterial efficacy is proved by both in vitro and in vivo tests, with low-power NIR irradiation for 10 min. Besides, the designed nanostructure in the metasurface itself also shows excellence in enhancing the adhesion-related gene expression of human gingival fibroblasts that are exposed to 10 min of NIR irradiation, proving the potent nanostructure-induced biological effects. This work provides a biosafe and upscalable metasurfacing approach with extraordinary capacity of manipulating light adsorption, photocatalysis, and biological properties.
植入物相关的微生物感染是一个具有挑战性的临床问题，其治疗需要有效清除植入物表面的生物膜。近红外（NIR）响应策略作为一种新兴的高效抗菌疗法被提出。然而，现有方法中使用的光敏剂或光催化/光热纳米材料可能会引发界面恶化和生物安全性受损的高潜在风险。在此，通过新发明的基于拓扑化学转化的酸碱双向水热法（aaBH）在钛合金植入物上制备了具有强大近红外响应抗菌活性的TiO₂/TiO₂超表面。电磁模拟证明，超表面的近红外吸收和近场分布可通过纳米结构单元的尺寸和排列进行调节。体外和体内试验均证明了其良好的抗菌效果，低功率近红外照射10分钟即可。此外，超表面中设计的纳米结构本身在增强暴露于10分钟近红外照射的人牙龈成纤维细胞的黏附相关基因表达方面也表现出色，证明了强大的纳米结构诱导的生物学效应。这项工作提供了一种生物安全且可扩展的超表面制备方法，具有操纵光吸收、光催化和生物学特性的非凡能力。
