Ge Min, Jiang Feng, Lin Han
Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Mater Today Bio. 2024 Sep 16;29:101255. doi: 10.1016/j.mtbio.2024.101255. eCollection 2024 Dec.
The rapid rise of antibiotic-resistant strains and the persistence of biofilm-associated infections have significantly challenged global public health. Unfortunately, current clinical high-dose antibiotic regimens and combination therapies often fail to completely eradicate these infections, which can lead to adverse side effects and further drug resistance. Amidst this challenge, however, the burgeoning development in nanotechnology and nanomaterials brings hopes. This review provides a comprehensive summary of recent advancements in nanomaterials for treating bacterial infections. Firstly, the research progress of catalytic therapies in the field of antimicrobials is comprehensively discussed. Thereafter, we systematically discuss the strategies of nanomaterials for anti-bacterial infection therapies, including endogenous response catalytic therapy, exogenous stimulation catalytic therapy, and catalytic immunotherapy, in order to elucidate the mechanism of nanocatalytic anti-infections. Based on the current state of the art, we conclude with insights on the remaining challenges and future prospects in this rapidly emerging field.
抗生素耐药菌株的迅速增加以及生物膜相关感染的持续存在，给全球公共卫生带来了重大挑战。不幸的是，当前临床高剂量抗生素方案和联合疗法往往无法完全根除这些感染，这可能导致不良副作用和进一步的耐药性。然而，在这一挑战中，纳米技术和纳米材料的蓬勃发展带来了希望。本综述全面总结了用于治疗细菌感染的纳米材料的最新进展。首先，全面讨论了抗菌领域催化疗法的研究进展。此后，我们系统地讨论了纳米材料用于抗菌感染治疗的策略，包括内源性反应催化疗法、外源性刺激催化疗法和催化免疫疗法，以阐明纳米催化抗感染的机制。基于当前的技术水平，我们最后对这个快速发展的领域中仍然存在的挑战和未来前景提出了见解。
