Computer models evaluating hand tremors in Parkinson's disease patients.

One of the most characteristic signs of Parkinson's disease (PD) is hand tremor. The MDS-UPDRS scale evaluates different aspects of the disease. The tremor score is a part of the MDS-UPDRS scale, which provides instructions for rating it, by observation, with an integer from 0 to 4. Nevertheless, this form of assessment is subjective and dependent on visual acuity, clinical judgment, and even the mood of the individual examiner. On the other hand, in many cases, existing computational models proposed to resolve the disadvantages of the MDS-UPDRS scale may have uncertainty in differentiating a category of a slight Parkinson tremor from voluntary movements. In this study, 554 measurements from Parkinson's patients, and 60 measurements from healthy subjects, were recorded with inertial sensors placed on the back of each hand. Five biomechanical indicators characterised the hand tremor. With these indicators, the three fuzzy inference models proposed can differentiate, in the first instance, the presence of postural or resting tremor from a normal movement of the hand, and if detected, to determine its severity. The fuzzy inference models allowed following the criteria of the MDS-UPDRS scale, providing an evaluation with an accuracy of two decimal digits and which, due to its simplicity, can be implemented in clinical environments. The assessments of three experts validated the computer model.